Interactions between predicted PROTACs and the CRBN-target protein complex structures.

Abstract

(a) Ligand-target interactions between the PROTAC and the complex structure for P12757. (b) 2D ligand-target interactions between the PROTAC and the complex structure for P12757. A and B represent the chain ID for P12757 and CRBN, respectively. (c) Ligand-target interactions between the PROTAC and the complex structure for Q9UER7. (d) 2D ligand-target interactions between the PROTAC and the complex structure for Q9UER7. B and C represent the chain ID for CRBN and Q9UER7, respectively. (e) Ligand-target interactions between the PROTAC and the complex structure for Q9H1I8. (f) 2D ligand-target interactions between the PROTAC and the complex structure for Q9H1I8. A and B represent the chain ID for Q9H1I8 and CRBN, respectively. Cyan sticks represent interacting residues on CRBN and green sticks represent interacting residues on the target protein. Yellow balls and sticks represent the ligand structure. Color representations for interaction types are shown in the figure legend.</p

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