Do Unrecognized Neurodegenerative Diseases Impact Age-Related Eye Disease Research Outcome Measures?

Abstract

Age-related neurodegenerative diseases (NDDs) that lead to dementia, such as Alzheimer's disease, Parkinson's disease, and Lewy Body Dementia, result in retinal degeneration and brain-related visual dysfunction. Given that recognition of dementia-related NDDs, a significant portion of participants in age-related eye disease studies could harbor an undiagnosed NDD that impacts retinal OCT and visual quality of life measures.1-5 Our long-term goal is to determine whether screening for NDDs and controlling for NDD-associated retinal and visual quality of life changes is necessary in age-related eye disease research. The objective of this pilot study is to investigate the relationship between NDD screening measures and retinal OCT and visual quality of life measures in a control cohort within an age-related macular degeneration (AMD) registry

    Similar works