International Journal of Exercise Science 14(2): 1375-1387, 2021. Caffeine (CAF) has been extensively studied for its ergogenic and analgesic effects during exercise. However, the majority of these studies have been conducted in male populations. This study investigated the effects of acute CAF chewing gum on self-selected exercise intensity during a rating of perceived exertion (RPE) production trial in active females (n = 16, 21.0 ± 2.8 y). Data were also analyzed based on habitual CAF consumption level. Participants completed a V̇O2peak trial, followed by a familiarization and two randomized, triple-blinded experimental RPE production trials on an arm ergometer [clamped resistance, blinded to self-selected cadence (CAD)] with either CAF gum (300 mg; 4.8 ± 0.7 mg/kg-1 body mass) or placebo (PLA), at a prescribed RPE of 4 and 7 (10 min each). Self-selected CAD did not statistically differ (p \u3e 0.05) between CAF or PLA for an RPE4 (37.7 ± 1.6 vs. 37.6 ± 1.6 rev·min-1) or RPE7 (42.9 ± 1.6 vs. 41.2 ± 1.7 rev·min-1), respectively. There were no statistical differences between treatment groups for any other variables, except restlessness rating which was significantly higher (3.5 vs. 2.2; p = 0.03, d = 0.64) for the CAF group compared to PLA. Secondary analysis revealed no statistical differences for any variables between habitual consumers of low (23 ± 20 mg/day) or mod/high (195 ± 93 mg/day) CAF. Our data support previous studies examining CAF in women across different testing modalities and suggest that regardless of habitual CAF consumption, females might require higher doses of CAF to replicate subjective and physiological responses commonly observed using similar RPE production protocols in male participants. These findings support the need for additional investigations into female physiological and perceptual responses following CAF ingestion
