Oligo-CS effectively inhibits differentiation of RAW264 cells into osteoclasts.

Abstract

(A) RAW264 cells were grown in differentiation medium for 5 days to differentiate into osteoclasts. The control cells were grown in differentiation medium without sRANKL. Then the cells were subjected to TRAP staining. (B) RAW264 cells were grown in differentiation medium with the indicated concentrations of CS or Oligo-CS for 5 days, and the cells were subjected to TRAP staining. (C) The TRAP positive mature multinuclear cells were counted under a microscope. Error bars indicate standard deviations calculated from at least 19 frames of each group. Asterisks (*) shown in the graph indicate that the difference is statistically significant (p < 0.05) compared to the control.</p

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