Comparison of prognostic risk scores after successful primary percutaneous coronary intervention

Abstract

Background The aim of this study was to compare the predictive ability of clinical risk scores (ACEF, EuroSCORE and EuroSCORE II) to angiographic (SYNTAX score) and combined risk scores (Global Risk Score and Clinical SXscore) towards cardiovascular death and/or major adverse cardiac events (MACE) in patients with ST-segment elevation acute myocardial infarction (STEMI) managed with primary percutaneous coronary intervention (pPCI). Methods A total of 685 patients successfully treated with pPCI were evaluated and the risk scores were calculated. The primary endpoint was the 2-year incidence of fatal cardiac events. Secondary end points were target lesion failure (TLF), repeat revascularization (RR) and MACE. Results Patients distributed in the highest tertile of EuroSCORE II presented increased rates of CV death (CVD), all-cause mortality and MACE (p < 0.001 for all). EuroSCORE II was associated with increased C-statistics (0.873, 95% CIs: 0.784–0.962 and 0.825, 95% CIs: 0.752–0.898 respectively) for predicting CVD and MACE over competing risk scores (p < 0.05). EuroSCORE II conferred incremental discrimination (Harrell's C, p < 0.05 for all, apart from CSS for predicting CVD) and reclassification value (Net Reclassification Index, p < 0.05 for all, apart from CSS for reclassifying MACE) over alternative risk scores for study's main endpoints. EuroSCORE II independently predicted CVD (HR = 1.06, 95% CIs: 1.03–1.09, p < 0.001) and MACE (HR = 1.07, 95% CIs: 1.04–1.10, p < 0.001). Conclusion EuroSCORE II has the best predictive ability of CVD and/or MACE after successful pPCI for the treatment of STEMI. © 2016 Elsevier Ireland Lt