A case is presented of a 30-year-old man, prescribed zolpidem for
insomnia arising from cocaine abuse, who sought to use this hypnotic to
reduce his craving for cocaine. However, after taking cocaine and up to
300 mg/day zolpidem, he became euphoric and hyperactive. It is suggested
that at high doses, zolpidem, like cocaine, has a stimulatory effect on
the brain dopaminergic reward pathway
