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Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma
Authors
S. Danielides Mavragani, C.P. Katsakoulas, I. Zintzaras, E. Drosos, A.A. Vlachoyiannopoulos, P.G. Moutsopoulos, H.M.
Publication date
1 January 2011
Publisher
Abstract
Objectives: Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. Methods: A total of 138 patients with SSc [46 with diffuse (dSSc) and 92 with limited scleroderma (lSSc)] and 100 healthy controls (HC) were tested for the presence of ATA [anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies] using a commercial enzyme-linked immunosorbent assay (ELISA). Clinical and serological data were recorded. Results: An increased prevalence of anti-TPO but not anti-Tg antibodies was detected in patients with SSc compared to HC (27.5% vs. 14%, p = 0.016). Of note, a statistically significant increase of anti-TPO was detected only in patients with lSSc compared to HC (32.6% vs. 14%, p = 0.003). No correlations with other clinical features were detected. Conclusions: An increased prevalence of anti-TPO antibodies was identified in patients with lSSc. We propose that ATA testing should be offered to this subgroup of patients. © 2011 Informa Healthcare on behalf of The Scandinavian Rheumatology Research Foundation
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Last time updated on 10/02/2023