Nanoscale Superconducting QUantum Interference Devices (SQUIDs) have spin sensitivities approaching that required to detect the flip of a single spin in close proximity. There is considerable interest in developing them for measuring the properties of small spin populations in magnetic systems. It is desirable that such measurements can be realised at sub-kelvin temperatures thereby allowing the study of magnetic systems that undergo phase changes at such temperatures. However, most nanoscale SQUIDs use nanobridges as the Josephson elements which limits the operating range to temperatures close to the transition temperature of the device. Well below this, the current-phase relation can become non-sinusoidal, and hot spots arising from the large critical current lead to hysteretic I-V characteristics. To extend the temperature range downwards, we have developed a range of nanoSQUIDs fabricated from alternative materials with lower transition temperatures including Ti/Au and Al/Ag bilayers patterned using lift-off and e-beam lithography (EBL). We report on their I-V characteristics, noise performance and behaviour in applied magnetic fields at temperatures down to 60 mK. We discuss theoretical analysis and computer modelling of the heat flow in the nanobridge structure, and consider the effects of bank geometry and kinetic inductance on the overall device performance. Finally, we present measurements of several magnetic systems: control lines, superconducting islands and ground planes and discuss the feasibility of magnetic measurements of novel materials of interest, including the heterointerface between lanthanium aluminate and strontium titanate
