English, Carolyn J

Jones, Mark

Lohning, Anna E

Mayr, Hannah L

Reidlinger, Dianne P

BioFactors

English

Carolyn J. English

Anna E. Lohning

Hannah L. Mayr

Mark Jones

Dianne P. Reidlinger

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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase<scp>A<sub>2</sub></scp>activity and traditional cardiovascular risk factors

Traditionally cardiovascular disease (CVD) risk has been assessed through blood lipids and inflammatory marker C-reactive protein (hsCRP). Recent clinical interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) recognizes that vascular damage can exist in the absence of traditional risk factors. This cross-sectional study investigated the potential relationship between circulating PAF, Lp-PLA 2 , hsCRP, and traditional risk factors for CVD. One hundred adults (49 ± 13 years, 31% male) with variable CVD risk were recruited. Fasting inflammatory markers PAF, Lp-PLA 2 and hsCRP and total, high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol, and triglycerides were measured. Blood pressure, body mass index, and waist circumference were measured. Medical and physical activity data were self-reported. Linear and multiple regressions were performed. PAF, Lp-PLA 2 , and hsCRP independently correlated with several CVD risk factors. PAF was correlated significantly with risk factors in an unexpected way; there was a medium positive correlation between PAF and HDL cholesterol (r = 0.394, p &lt; 0.001) and medium negative correlations with Total:HDL cholesterol; (r = -0.436, p &lt; 0.001) systolic blood pressure; (r = -0.307, p = 0.001); BMI (r = -0.381, p &lt; 0.001); and waist circumference (r = -0.404, p &lt; 0.001). There were large positive correlations between Lp-PLA 2 and LDL (r = 0.525, p &lt; 0.001) and non-HDL cholesterol (r = 0.508, p &lt; 0.001). There were large positive correlations between hsCRP and Total:HDL cholesterol (r = 0.524, p &lt; 0.001); BMI (r = 0.668, p &lt; 0.001); and waist circumference (r = 0.676, p &lt; 0.001). PAF, Lp-PLA 2 , and hsCRP are implicated in the pathophysiology of inflammation in CVD; however, the relationships between each marker and traditional risk factors were different suggesting they may be involved in different atherogenic pathways. </p

Bond University Research Portal

Interrelationships among platelet-activating factor and lipoprotein-associated phospholipase A2 activity and traditional cardiovascular risk factors

https://pure.bond.edu.au/ws/files/202810875/Interrelationships_among_platelet_activating_factor.pdf

Interrelationships among platelet-activating factor and lipoprotein-associated phospholipase A2 activity and traditional cardiovascular risk factors

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