The chemical potential change provides a criterion for predicting the spontaneity of any physical and chemical process. If asked to calculate the chemical potential change of a system in which several forces vary, a student might find the task quite complicate at first glance. However, the chemical potential is a state function. This property permits a precise definition of the contribution of each force to the chemical potential when all other relevant parameters are kept constant. The total chemical potential change can easily be calculated by summing up the above contributions. After a brief review of the role played by some parameters of the system, like activity (a) of the components, temperature (T), pressure (p) and surface tension (gamma), as well as of external fields, i.e. gravitational (Mgh), centrifugal (Mcp) and electric field (Fz(i) Phi), an equation for the computation of the chemical potential (mu) including all the above contributes is reported:-, where refers not only to p = p degrees = 1 bar but also to a chosen value of T, h, rho, Phi and r. Finally, applicative examples are illustrated.The chemical potential change provides a criterion for predicting the spontaneity of any physical and chemical process. If asked to calculate the chemical potential change of a system in which several forces vary, a student might find the task quite complicate at first glance. However, the chemical potential is a state function. This property permits a precise definition of the contribution of each force to the chemical potential when all other relevant parameters are kept constant. The total chemical potential change can easily be calculated by summing up the above contributions. After a brief review of the role played by some parameters of the system, like activity ( of the components, temperature (T), pressure (p) and surface tension (), as well as of external fields, i.e. gravitational (ℎ, centrifugal () and electric field (Φ), an equation for the computation of the chemical potential (µ) including all the above contributes is reported: °′ ° ° ℎ Φ 2 , where ° refers not only to p = p° =1 bar but also to a chosen value of T, h, ρ, Φ and r. Finally, applicative examples are illustrated