Background: Worldwide, health care professionals are facing unprecedented stress levels due to the continuing COVID-19 pandemic. Methods: A rapid systematic review of peer-reviewed studies examining psychological symptoms in HCW working during COVID-19 pandemic in early 2020. 13,999 participants were included. Results: After 3408 studies were screened for inclusion, 10 were included in the final analysis. About half of HCW presented with possible PTSD (i.e. scored above a clinical cutoff). Limitations: An update of the search should be conducted. Conclusions: These initial studies suggest a high rate of possible PTSD diagnosis in frontline HCW