Enyedy Éva Anna

Mészáros János P.

Poljarevic Jelena

Tomaz Ana Isabel

English

University of Szeged

27th International Symposium on Analytical and Environmental Problems  212  THE SOLUTION CHEMICAL BEHAVIOUR OF OXORHENIUM(V) AND HALF-SANDWICH RUTHENIUM(II) COMPLEXES CONTAINING A TRIPHENYLPHOSPHINE LIGAND  János P. Mészáros1, Ana Isabel Tomaz2, Jelena Poljarevic3, Éva A. Enyedy1  1MTA-SZTE Lendület Functional Metal Complexes Research group, Department of Inorganic and Analytical Chemistry, University of Szeged, H-6720 Szeged, Dóm tér 7, Hungary 2Centro de Química Estrutural, Faculdade de Ciencias, Universidade de Lisboa, 1749-016 Lisbon, Campo Grande 016, Portugal 3Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Studentski trg 12–16, Serbia e-mail: meszaros.janos@chem.u-szeged.hu  Abstract In the chemotherapeutic therapy of cancer there is an urgent need for the novel compounds, which have higher selectivity toward cancer cells and their use is accompanied with milder side-effects. In the field of inorganic medicinal chemistry a plethora of metal complexes with promising in vitro cytotoxic behavior was developed containing various metal ions (e.g. Cu(II), Au(III), Ru(II/III)) [1]. Complexes of Re(I) and Re(V) showed anticancer properties, and the latter group is able to cleave DNA [2]. Moreover, oxorhenium(V) complexes are catalyzing oxygen atom transfer reactions [3], which may occur intracellularly as well. The organometallic half-sandwich Ru(II) complexes containing cyclopentadiene (Cp) and triphenylphosphine (PPh3) ligands were reported to exhibit anticancer activity in vitro and in vivo [4].  In this work I will introduce the different behavior of the PPh3 containing Re(V) and Ru(II) complexes in solution (structures are shown in Figure 1.a,b). Synthesis and characterization of the complexes were followed and checked by 31P and 1H NMR spectroscopy. For a RuCp complex, a single-crystal was also obtained which was suitable for X-ray diffraction analysis (Figure 1.c).   Figure 1. General structure of the studied a) RuCp and b) Re(V) complexes. c) ORTEP view of [RuCp(4,4’-dimethoxy-2,2’-bipyridine)(PPh3)](CF3SO3)] complex.   Since phosphines are generally oxygen-sensitive, oxidation of the coordinated PPh3 ligand was followed by 31P NMR spectroscopy. The compounds were dissolved in different organic solvent-water mixtures and their stability in solution was monitored by UV-visible spectrophotometry and 1H and 31P NMR spectroscopy as well. The two complex families displayed remarkable differences in their solution chemical properties.    27th International Symposium on Analytical and Environmental Problems  213  Acknowledgements Supported by the ÚNKP-21-4-SZTE-493 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund and by the Portuguese-Hungarian Scientific & Technological Cooperation Mobility support for bilateral research project (2019-22; TÉT-PT-2018-00002).  References [1] E. Alessio, Z. Guo, Eur. J. Inorg. Chem. (2017) 1539–1540. [2] C. C. Konkankit, S. C. Marker, K. M. Knopf, J. J. Wilson, Dalton Trans. 47 (2018) 9934–9974. [3] A. M. Kirillov, M. Haukka, M. V. Kirillova, A. J. L. Pombeiro, Adv. Synth. Catal. 347 (2005) 1435–1446. [4] F. C. Santos, P. J. Costa, M. H. Garcia, T. S. Morais, Biometals 34 (2021) 1029–1042.   

The solution chemical behaviour of oxorhenium(V) and halfsandwich ruthenium(II) complexes containing a triphenylphosphine ligand

http://acta.bibl.u-szeged.hu/75967/1/proceedings_of_isaep_2021_212-213.pdf

The solution chemical behaviour of oxorhenium(V) and halfsandwich ruthenium(II) complexes containing a triphenylphosphine ligand

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