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Chlorpyrifos Induced Region Specific Vulnerability in Rat CNS and Modulation by Age and Cold Stress: An Interactive Study

Abstract

Chlorpyrifos (CPF)​, an organophosphorus insecticide is known to cause ill health in non-​target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-​related differences and vulnerability in central nervous system of rats. The results indicated an interaction with age and cold exposure resulting in marked decreased activity levels of SOD (P < 0.05)​, CAT (P < 0.05)​, GPx (P < 0.05)​, GST (P < 0.05) followed by increased MDA (P < 0.05) and decreased GSH levels (P < 0.05)​. The ANOVA and Post-​hoc anal. showed that antioxidant enzymes decreased significantly (P < 0.05) on CPF exposure. Moreover synergistic action of CPF and cold stress at 15°C caused higher inhibition on comparison with CPF and cold stress alone and together at 20°C indicating the extent of peroxidative damage in discrete regions of CNS. Further this study showed young individuals to be more sensitive than adults

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