Spike protein structures colored by conservation fraction with varying weights of the structural conservation fraction (F<sub>struc</sub>) and biochemical conservation fraction (F<sub>bio</sub>) using SARS-CoV-2 as a reference.

Abstract

Green residues have conservation fractions above 0.8, blue residues have conservation fractions below 0.8 and are not in the RBD, and red residues have conservation fractions below 0.8 and are in the RBD. (TIF)</p

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