Autosomal recessive hereditary ectodermal dysplasia (HED) has not been described in sub‑Saharan Africa. It is acknowledged to be rarer than the occasionally reported x‑linked and autosomal dominant variants. We report a pair of Nigerian female twins with family history and clinical features suggestive of recessive HED, thereby showing the existence of this rare form in sub‑Saharan Africa.Keywords: Anhidrotic, dysplasia, ectodermal, female, hypohidroticNigerian Journal of Clinical Practice •Jan-Mar 2012 • Vol 15 • Issue