The articles presents materials of the three defended and approved doctor’s dissertations, devoted to individual approaches to children ill with tuberculosis and having the risks of developing tuberculosis depending on social conditions, state of the host, cellular and molecular-genetic levels. The options of working with children and adolescents being within the studied categories, basing on the innovative computer technology have been o|ered. The examples are given how the innovative approaches have been introduced into the practical works of pediatricians and TB pediatricians