Amyotrophic lateral sclerosis presenting with orthopnea in a patient with COPD and obstructive sleep apnea


Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) is a relentlessly progressive neurological disorder causing peripheral muscular weakness and resultant respiratory failure. In this article, we report a case of ALS with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) with orthopnea as initial symptoms

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