Preparação de derivados do lapachol em meio ácido e em meio básico: uma proposta de experimentos para a disciplina de Química Orgânica Experimental Preparation of lapachol derivatives in acid and base media: proposed experiments for Organic Chemistry laboratory classes

Abstract

<abstract language="eng">In this educational paper we describe the extraction of lapachol from its natural source according to acid-base concepts in organic chemistry and the use of its derivatives &#946;-lapachone and hydroxy-hydrolapachol to exemplify intramolecular cyclization, carbocation stability, Michael addition reaction and chromatography. The experiments were performed during three different undergraduate organic chemistry laboratory classes using low cost material, while avoiding color reagents for TLC visualization, as well as small-scale column chromatography to isolate the mixture of lapachol and &#946;-lapachone