CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
Authors
Alexandra Baecklund
Quinte Braster
+29 more
Chien Sin Chen
Ingo Hilgendorf
Julia Hinterdobler
Michael Hristov
Maarten Hulsmans
Hong Jin
Wolfgang E. Kempf
Thorsten Kessler
Markus Krane
Karl Heinz Ladwig
Peter Libby
Lars Maegdefessel
Carina Mauersberger
Almut Meesmann
Aldo Moggio
Michael Molitor
Philipp Müller
Matthias Nahrendorf
Hendrik B. Sager
Christoph Scheiermann
Simin S. Schott
Heribert Schunkert
Oliver Soehnlein
Anna Lena Steinsiek
Baiba Vilne
Christian Weber
Philip Wenzel
Jana Wobst
Anna Sophia Zimmermann
Publication date
1 January 2021
Publisher
'Oxford University Press (OUP)'
Doi
Cite
Abstract
Publisher Copyright: © 2021 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology.Aims: Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear. Methods and results: Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques. Mechanistically, we found that acute stress enhances leucocyte influx into mouse atherosclerotic plaques by modulating endothelial cells. Specifically, acute stress increases adhesion molecule expression and chemokine release through locally derived norepinephrine. Either chemical or surgical disruption of norepinephrine signalling diminished stress-induced leucocyte migration into mouse atherosclerotic plaques. Conclusion: Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.publishersversionPeer reviewe
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
PuSH
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:opus-zb.helmholtz-muenchen...
Last time updated on 05/12/2021
Open Access LMU
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:epub.ub.uni-muenchen.de:98...
Last time updated on 22/06/2024
NARCIS
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 18/10/2022
Riga Stradins university
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.rsu.lv:123456789/70...
Last time updated on 26/12/2021
Archive ouverte UNIGE
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:unige.ch:aou:unige:156530
Last time updated on 07/06/2024