Eri Miyamoto-Mikami

Hirofumi  Zempo

Hiroshi Kumagai

Naoki Kikuchi

Nobuhiro  Kamiya

Noriyuki  Fuku

P(論文)https://www.tsc-05.ac.jp/pdf_library/2021.pdfdepartmental bulletin pape

Kumagai, Hiroshi

21762

Miyamoto-Mikami, Eri

21763

Kikuchi, Naoki

21764

Kamiya, Nobuhiro

21765

Zempo, Hirofumi

21766

Fuku, Noriyuki

21767

Tokyo Seiei College Repositories / 東京聖栄大学 リポジトリ

－ 1 －再録 報文J Strength Cond Res (2020) Oct 9. Online ahead of print. A rs936306 C/T polymorphism in the CYP19A1 is associated with stress fractures. Hiroshi Kumagai1,2, Eri Miyamoto-Mikami1, Naoki Kikuchi3, Nobuhiro Kamiya4, Hirofumi Zempo5 and Noriyuki Fuku11Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. 2Research Fellow of Japanese Society for the Promotion of Science, Tokyo, Japan. 3Department of Training Science, Nippon Sport Science University, Tokyo, Japan. 4Faculty of Budo and Sport Studies, Tenri University, Nara, Japan. 5Faculty of Health and Nutrition, Tokyo Seiei College, Tokyo, Japan. Abstract Background: A stress fracture (SF) is an overuse injury, and low bone mineral density (BMD) is the risk factor for the SF. Estrogen is suggested to have a crucial role in bone metabolism, and estrogen-related genetic polymorphisms are associated with BMD. However, the possible association between SF and estrogen-related genetic polymorphisms has not been clarified yet. Therefore, we aimed to clarify whether estrogen-related genetic polymorphisms are associated with a history of SFs in Japanese athletes. Methods: A total of 1,311 (men: n = 868, women: n = 443) top-level Japanese athletes who participated in various sports and at different levels were analyzed. The history of SFs was assessed using a questionnaire, and the cytochrome P450 aromatase gene (CYP19A1) rs936306 C/T and estrogen receptor α gene (ESR1) rs2234693 T/C polymorphisms were analyzed using the TaqMan genotyping assay. Results: The genotype frequency of the CYP19A1 C/T polymorphism was significantly different between the injured group and noninjured group under the C allele additive genetic model (odds ratio = 1.31, 95% confidence interval = 1.01-1.70), especially in men and in women with irregular menstruation. On the other hand, there were no significant differences with the ESR1 T/C polymorphism. Conclusions: This study demonstrated that the C allele in the CYP19A1 rs936306 polymorphism is a risk factor for SFs in top-level Japanese athletes. － 18 －

A rs936306 C/T polymorphism in the CYP19A1 is associated with stress fractures.

https://tsc.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3911&item_no=1&attribute_id=18&file_no=1

A rs936306 C/T polymorphism in the CYP19A1 is associated with stress fractures.

Abstract

Similar works

Full text

Available Versions

Tokyo Seiei College Repositories / 東京聖栄大学リポジトリ

A rs936306 C/T polymorphism in the CYP19A1 is associated with stress fractures.

Abstract

Similar works

Full text

Available Versions

Tokyo Seiei College Repositories / 東京聖栄大学 リポジトリ

Tokyo Seiei College Repositories / 東京聖栄大学リポジトリ