Panwar, Kusum

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IIT Gandhinagar

  Page | vi     Abstract              Title of Document: POLYMORPHISM AND PARTICLE FORMATION PATHWAYS OF POORLY WATER SOLUBLE DRUGS DURING SONOPRECIPITATION FROM [BMIM][Cl] SOLUTIONS USING WATER AS AN ANTISOLVENT  Kusum Panwar, M.Tech , 2018  Directed By:  Dr. Sameer V. Dalvi Associate Professor  Discipline of Chemical Engineering     One of the major challenges being faced by the pharmaceutical industry is the poor water solubility of majority of drugs in the industry pipeline. In order to enhance the aqueous solubility, these drugs can be precipitated as nanoparticles. Carbamazepine (CBZ) known as an anticonvulsant and anti-epileptic drug is poorly water soluble, which limits its efficacy as drug. In this work we have used liquid antisolvent precipitation to precipitate CBZ from its solutions in Ionic liquid.  [BMIM][Cl] is used as solvent and water has been used   Page | vii    as an antisolvent. Ultrasound was used to enhance mixing and additives such as Tween80, Hydroxypropylmethylcellulose (HPMC), Bovine Serum Albumin (BSA) and Polyvinylpyrrolidone (PVP) were used to control the particle growth. The precipitated particles were characterized for particle size distribution, morphology and polymorphic content. Interestingly, most of the experiments resulted in the precipitation of Form 1(triclinic) of CBZ whereas Form 3(P-monoclinic) was obtained when liquid antisolvent precipitation was carried out with ultrasound and without additive and with ultrasound and Tween80 as additive.  Further the particles precipitated under all conditions were found to be long needle shaped with each individual needle made of several smaller needles. These CBZ particles seem to follow a non-classical crystallization pathway in the beginning which is followed by the secondary nucleation and growth. The dissolution studies performed for these particles show that the particles precipitated by LAS exhibited higher dissolution than the raw CBZ.   Keywords: Ionic liquids, Carbamazepine, ultrasound, liquid antisolvent.   

Polymorphism and particle formation pathways of poorly water soluble drugs during sonoprecipitation from [BMIM][C] solutions using water as antisolvent

https://repository.iitgn.ac.in/bitstream/handle/123456789/4092/Abstract%20%20Kusum%20panwar-16210044.pdf?sequence=1&isAllowed=y

Polymorphism and particle formation pathways of poorly water soluble drugs during sonoprecipitation from [BMIM][C] solutions using water as antisolvent

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