Methods are described in the framework of light-cone expansion which allow
one to determine the Cabibbo-Kobayashi-Maskawa matrix elements |V_ub| and
|V_cb| from measurements of the differential decay rates as a function of the
scaling variables in the inclusive semileptonic decays of B mesons. By these
model-independent methods the dominant hadronic uncertainties can be avoided
and the B -> X_u\ell\nu decay can be very efficiently differentiated from the B
-> X_c\ell\nu decay, which may lead to precise determinations of |V_ub| and
|V_cb|.Comment: 11 pages, 2 figures, version as published in Mod. Phys. Lett. A, more
discussion, references added, title chang