CBSE-2014 [2 nd and 3 rd April 2014] Challenges in Biochemical Engineering and Biotechnology for Sustainable Environment Hepatic Antioxidant and Lipid Peroxidative Efficacy of Aqueous Extract of Boerhaavia Diffusa (Linn.) against Antituberculosis Drug Rif

Abstract

Abstract : Numbers of plant remedies have been used by traditional practitioners for the treatment of liver disorders for centuries. The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The aqueous extract of Boerhaavia diffusa leaves was investigated for its antioxidant and lipid peroxidative efficacy on antituberculosis drug rifampicin (1g/kg) induced liver damage in male albino wistar rats. Antioxidant and lipid peroxidative activity was measured by using biochemical parameters such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and TBARS in liver. Oral administration of the aqueous leaf extract of Boerhaavia diffusa at the doses of (125, 250 and 500 mg/kg) to rifampicin treated rats produced significant antihepatotoxic effect by decreasing the level of TBARS and enhance the levels of antioxidant activity in liver. The effects aqueous leaf extract of Boerhaavia diffusa were comparable to standard drug silymarin. These results suggest that aqueous leaf extract of Boerhaavia diffusa have potential therapeutic value in the treatment of liver diseases, probably by its antioxidative efficacy in liver