Abstract: This paper extends the experimental and numerical results presented previously and addresses the major criticisms raised. In addition, the most recent results are discussed. In acoustic cavitation experiments with chilled (0 8C) deuterated acetone (C 3 D 6 O), the production of tritium and 2.45 MeV neutrons [which are characteristic of deuterium-deuterium (D -D) fusion] was observed during vapour bubble implosions in an acoustic pressure field. Similar experiments with deuterated acetone at room temperature (20 8C) and control experiments with normal acetone (C 3 H 6 O), at both 0 and 20 8C, showed no statistically significant increases in either tritium level or neutron emissions. Numerical simulations of the processes that account for the shock waves generated in the liquid and within the collapsing bubbles supported these experimental observations and showed that high densities and temperatures (510 8 K) may be achieved during bubble cloud implosions, yielding the conditions required for D -D nuclear fusion reactions. The present paper treats the bubble fusion experiments and theoretical results in greater detail than was possible in the previous publications, contains some refinements, addresses some important questions raised by reviewers and critics and discusses possible applications of this interesting phenomenon