UVA Assisted 4-Thiothymidine for Cancer Treatment

This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given

复合增效抗氧化剂对降低猪油贮存中脂肪氧化的影响

油脂抗氧化剂的使用对于保证油脂及富含油脂饲料的品质及延长贮存时间有重要的意义。本文研究了目前广泛应用的单体饲料抗氧化剂及复合抗氧化剂对动物性油脂猪油的抗氧化性能。结果表明:相对于单一组分抗氧化剂,复合抗氧化剂各成分之间的协同增效作用提高了抗氧化性能,对延长油脂贮存时间有显著的提高,采用复合抗氧化剂也是降低使用成本的有效途径之一

青草植物抗氧化評估之灰關聯分析與灰決策

[[abstract]]本研究檢測九種青草植物其水相與甲醇相之抗氧化成分、抗氧化功能性及抗氧化力。抗氧化成分包括類黃閩、單寧、比林類、類胡蘿蔔素及多酌類。青草植物包括車前草、成豐草、拘紀葉、甘藉葉、台灣百合、雷公根、皺葉薄荷、野薄荷及仙草等。抗氧化功能性包括還原力、清除DPPH 自由基J 贅合亞鐵離子及清除超氧陰離子能力。抗氧化力包括亞麻油酸乳化系統共輒雙儒生成抑制性與LDL 遲滯期。並且利用灰關聯分析與灰決策分析抗氧化成分與抗氧化功能及抗氧化力間之相關性。結果，顯示，不同抗氧化成份在不同檢驗系統展現不同的貢獻度。水相與甲醇相萃取物之綜合表現，以成豐草之表現最佳。[[abstract]]The aim of this study was to evaluate the antioxidative substances, anti oxidative functions and anti oxidative capacity of nine herb plants, including Plantago asiatica Linn., Eidens pilosa Linn., Lycium chinense Mall., Ipomoea hatatas Linn., Lilium formosanum Wall., Centella asiatica (L.) Urban., Mentha crispa Menth., Mentha arvensis L. var. piperascens Malinv., Mesona procumhens Hemsley.. The anti oxidative substances include flavonoids, tannin, porphyrins, carotenoids, polyphenol. The antioxidative functions, such as reducing power, chelating Fe2+ ion, scavenging of DPPH radicals and superoxide anion were determined. The antioxidative capacity includes the inhibition percentage of conjugated diene formation in the linoleic acid emulsion system and the delay of lag phase of LDL. The correlation between antioxidative compositions, antioxidative functions and antioxidative capacity is analyzed. Meanwhile, the grey relation analysis and grey decision analysis are employed to analyze the interaction among the three.[[sponsorship]]雲林科技大學水土資源及防災科技研究中心[[conferencetype]]國內[[conferencedate]]20011025~20011026[[booktype]]紙本[[iscallforpapers]]Y[[conferencelocation]]雲林縣, 臺

食品级抗氧化剂(TBHQ)及其衍生物在饲料中的抗氧化能力

本文综述了饲料抗氧化剂TbHQ及其衍生物的抗氧化机理,抗氧化作用效果,抗氧化活性评价方法及其使用的安全性方面的研究进展

生物源抗氧化剂的研发及其在饲料中的应用前景

饲料中的油类、脂肪、类脂化合物如脂溶性维生素在贮运过程中易被氧化而产生酸败味和褪色,从而失去营养价值危害动物健康。如何提高饲料抗氧化能力成为饲料工业的挑战之一。生物源抗氧化剂具有安全性高、抗氧化能力强等优点,将在饲料工业领域具有广阔的应用前景。文章概述了饲料中容易氧化的主要成分及其环境影响因素,生物抗氧化剂的来源、活性成分和抗氧化作用机理以及生物源抗氧化剂在饲料中的应用,讨论了生物源抗氧化剂的开发与研究思路

The impact of iron metabolism system on a common mechanism of antimicrobial lethality

传统研究认为不同种类的抗生素有其各自不同的杀菌途径，然而近年人们发现了一条抗生素杀菌的共用通路，那就是当细菌细胞受到抗生素致死性刺激时，呼吸链将代谢异常产生大量活性氧簇（ROS），而铁离子对ROS介导的杀菌至关重要。本研究参阅近年来国内外研究结果，通过基因突变、铁离子竞争物等实验方法着重研究了细菌铁代谢系统与抗生素共有杀菌途径之间的关系，重点讨论抗生素刺激下铁离子的调控及其与抗生素介导ROS形成的相互作用关系。对于细菌耐药机制的研究与寻找新型药物作用靶点、开发新药有重要意义。 本研究对铁储存蛋白相关基因（dps、ftnA、ftnB、bfr）及铁调控蛋白相关基因（fur）进行了系统性的敲除，测...Previous work suggested that different antibiotics could kill bacteria via various targets or mechanisms respectively. However, a common mechanism of bactericidal antibiotics was reported recently. When bacteria suffered lethal stress by antibiotics, reactive oxygen species (ROS) was induced by abnormal respiratory chain reaction in which iron plays a key role. By reviewing current research progre...学位：医学硕士院系专业：公共卫生学院_流行病与卫生统计学学号：3272013115053

The association between the antioxidant property and ROS system in murine corneal epithelial progenitor cells

目的：活性氧（ROS）是体内产生的一种高活性分子，低浓度可以调节细胞代谢，基因转录和磷酸酶的活性，高浓度则会导致氧化损伤。目前，有关干细胞自身特性的研究越来越受到学者们的重视，但既往文献中关于干细胞对氧化应激反应以及应激条件下细胞内相关酶活性的变化规律却很少报道。本课题聚焦于，在过氧化氢（H2O2）诱导的氧化应激条件下，活性氧生成关键因子NOX4和抗氧化酶核转录因子NRF2在小鼠角膜上皮祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）中的不同作用及相关机制。 方法：利用小鼠角膜上皮祖细胞（TKE2）和成熟小鼠角膜上皮细胞（MCE）建立过氧化氢（H2O2）诱导的氧化应激细胞模型。首先我们通...Purpose: Reactive oxygen species (ROS) is a molecular of high activity produced in human body. It can regulate metabolism, gene transcription and phosphatase activity at low concentrations,while cause oxidative damage at higher concentrations.Nowadays,the stem cell propertities has increasingly aroused the public concern,but there are still few papers published about the the reponse and ...学位：医学硕士院系专业：医学院_药理学学号：2452013115356

Molecular mechanism of the role of ROS signaling pathway in the antioxidant properties of TKE2 cells

目的:目前ROS在干细胞生物学中的作用还没有得到充分说明和了解。在过氧化氢（H2O2）诱导的氧化应激条件下，我们比较小鼠角膜上皮祖细胞（TKE2）[1]和成熟的小鼠角膜上皮细胞（MCE）的不同反应，重点研究是角膜干细胞的抗氧化细胞特性及相关机制。 方法:以小鼠角膜上皮祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）为细胞模型，通过CCK8细胞活性实验检测不同浓度H2O2对小鼠角膜上皮的祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）的影响。利用H2O2处理细胞24小时后，通过流式细胞术检测细胞内ROS的水平，利用免疫荧光染色检测细胞内氧化应激标志物3-硝基酪氨酸(3-NT)表达情况，...Purpose: The role of ROS in stem cell biology is not fully illustrated and understood. In this present research we compare the different responses under condition of oxidative stress induced by hydrogen peroxide (H2O2) between lately developed murine corneal epithelial progenitor cells (TKE2) and mature murine corneal epithelial cells (MCE) and investigate the antioxidant properties of TKE2 cells ...学位：理学硕士院系专业：医学院_药理学学号：2452013115355

NiMx/SiO2 Prepared with Urea Precipitation : An Investigation on the Deactivation and Stability in Partial Oxidation of Methane (POM)

甲烷部分氧化（POM）制合成气是甲烷转化的有效途径，Ni基催化剂因价格便宜、反应活性高（反应活性与贵金属相当）成为甲烷部分氧化反应中应用最广泛的催化剂。但Ni基催化剂常因烧结、积炭而失活，尤以负载型Ni/SiO2催化剂为甚。因此，解决催化剂的失活问题，提高催化剂的抗积炭抗烧结性能，是提高甲烷部分氧化催化剂反应活性和稳定性的关键。 本工作以贵金属、其它过渡金属氧化物添加为出发点，采用尿素沉淀法制备了一系列NiMx/SiO2催化剂，结合XRD、TEM、XPS、H2-TPR等表征手段，考察了不同催化剂上甲烷部分氧化反应性能与催化剂理化性质之间的关系，并探究了影响催化剂反应性能与抗积炭性能的因素。其...Partial oxidation of methane (POM) into syngas is an important approach to the utilization of methane. Ni as an active component of the catalysts for POM has attracted enormous attention due to its high activity, along with its low price when compared with noble metals. However, Ni-based catalysts may be deactivated as a result of sintering and carbon deposition on them, especially for Ni/SiO2 cat...学位：理学硕士院系专业：化学化工学院_物理化学学号：2052013115164

三种湿地植物抗寒性的初步研究

在阶段性降温条件下,研究了三种常用湿地植物黄鸢尾(Iris pseudacorus L.)、花菖蒲(Iris ensata Thunb.)及水芹(Oenabthe javanica)叶片抗寒性相关生理指标(可溶性蛋白质含量、可溶性糖含量、游离脯氨酸含量、丙二醛含量、超氧化物歧化酶活性、过氧化物酶活性、过氧化氢酶活性以及细胞质膜相对透性)的变化。结果表明,冷锻炼使湿地植物通过对抗氧化酶活性及渗透性的调节来提高其机体的抗寒性。低温条件下,黄鸢尾的抗氧化酶活性显著增加,5℃时SOD活性是初始值的5.77倍;花菖蒲保持较高的CAT活性,5℃时其CAT活性是黄鸢尾CAT活性的8.95倍,是水芹CAT活性的3.77倍;水芹叶片中脯氨酸含量明显提高,温度和脯氨酸含量呈负相关(R=-0.755,P=0.050)。综合比较各项生理指标可以得到这三种湿地植物的耐寒性大小顺序依次为:黄鸢尾>花菖蒲>水芹