19,649 research outputs found

    Does early improvement in depressive symptoms predict subsequent remission in patients with depression who are treated with duloxetine?

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    PURPOSE: In this prospective study, we examined whether early reduction in depressive symptoms predicts later remission to duloxetine in the treatment of depression, as monitored using the Montgomery–Asberg Depression Rating Scale (MADRS). PATIENTS AND METHODS: Among the 106 patients who were enrolled in this study, 67 were included in the statistical analysis. A clinical evaluation using the MADRS was performed at weeks 0, 4, 8, 12, and 16 after commencing treatment. For each time point, the MADRS total score was separated into three components: dysphoria, retardation, and vegetative scores. RESULTS: Remission was defined as an MADRS total score of ≤10 at end point. From our univariate logistic regression analysis, we found that improvements in both the MADRS total score and the dysphoria score at week 4 had a significant interaction with subsequent remission. Furthermore, age and sex were significant predictors of remission. There was an increase of approximately 4% in the odds of remission for each unit increase in age, and female sex had an odds of remission of 0.318 times that of male sex (remission rate for men was 73.1% [19/26] and for women 46.3% [19/41]). However, in the multivariate model using the change from baseline in the total MADRS, dysphoria, retardation, and vegetative scores at week 4, in which age and sex were included as covariates, only sex retained significance, except for an improvement in the dysphoria score. CONCLUSION: No significant interaction was found between early response to duloxetine and eventual remission in this study. Sex difference was found to be a predictor of subsequent remission in patients with depression who were treated with duloxetine, with the male sex having greater odds of remission

    (平成26年度佐竹高子研究奨励賞受賞者研究発表)ヘルパーT細胞由来Bach2が気管支喘息に及ぼす影響について

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    第353回東京女子医科大学学会例会 平成28年2月27日(土) 東京女子医科大学総合外来センター5階 大会議

    (平成26年度中山恒明研究奨励賞受賞者研究発表)NMD-小胞体品質管理クロストーク機構の分子機構と生理的役割の解析

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    第353回東京女子医科大学学会例会 平成28年2月27日(土) 東京女子医科大学総合外来センター5階 大会議

    PQA(Personal Qualities Assessment)の有用性の検討--測れる?測れない?

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    平成27年度東京女子医科大学医学部・基礎系教室研究発表会 平成27年12月17日(木) 東京女子医科大学 臨床講堂

    Turbo spin-echo法による拡散強調画像が診断に有用であった感染を伴った皮膚洞の1例

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    第47回東京女子医科大学・神経懇話会 2016年1月26日(火) 東京女子医科大学総合外来センター5階 大会議

    母親の育児過誤が重症化に関与したと考えた小児アトピー性皮膚炎の1例

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    第353回東京女子医科大学学会例会 平成28年2月27日(土) 東京女子医科大学総合外来センター5階 大会議
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