30,170 research outputs found
Indiana Hospital Based RNs
The 2021 Indiana Registered Nurse Workforce Brief presents key data on Indiana RN workforce data trends. This brief highlights key findings for Hospital based RNs
Accounting education literature review (2022)
This review of the accounting education literature includes 109 articles published during 2022 in five accounting education journals: (1) Journal of Accounting Education, (2) Accounting Education, (3) Advances in Accounting Education: Teaching and Curriculum Innovations, (4) Issues in Accounting Education, and (5) The Accounting Educators’ Journal. We update 17 prior accounting education literature reviews by organizing and summarizing contributions to the accounting education literature made during 2022. Articles are categorized into five sections corresponding to traditional knowledge bases: (1) curriculum and instruction, (2) instruction by content area, (3) educational technology, (4) students, and (5) faculty. We summarize and describe the research technique of the empirical articles. Suggestions for research are presented. Articles classified as cases and instructional resources published in the same five journals during 2022 are tabulated in appendices categorized by instructional content area
Jennifer Price Mahoney: 2023 Open Education Award Winner
Jennifer Price Mahoney adopted two OER textbooks and used other freely available
teaching materials for three separate writing courses. It is important to note that OER
materials are being used in multiple courses in the Writing curriculum and that these
courses impact a signi cant number of students. Ms. Mahoney has also documented
the favorable reception of these materials by students, 67% of whom responded that
OER readings were more helpful than materials they had used in other online courses
Future Directions for Transforming Kinesiology Implementation Science Into Society
Physical activity policy can play a crucial role in ensuring that individuals, communities, and societies can obtain the wide range of health benefits associated with regular physical activity participation. Policies such as Title IX, the Americans With Disabilities Act, and state physical education laws have all increased opportunities for millions of Americans to participate in physical activity. With that said, how policies are developed and implemented vary considerably. The purpose of this manuscript is to contrast an academic conceptual framework with a pragmatic approach for policy implementation. In an ideal world, polices would be developed from foundational knowledge, scaled up to community-level interventions, and implemented in a sequential fashion. However, policy implementation is a disorderly process that requires a practical methodology. The National Physical Activity Plan encompasses strategies and tactics across 10 key societal sectors—and highlights the disorderly process of policy implementation across the various sectors
Pathways Toward Culturally Relevant and Sustaining Learning and Teaching
A visualization of the work necessary to foster an environment in which culturally relevant and sustaining learning and teaching can occur
Emergent Intervention of a Non-Communicating Rudimentary Uterine Horn Pregnancy
Background:
Non-communicating rudimentary uterine horns (NRCH) arise from Mullerian duct malformations during embryonic development. Pregnancies of the rudimentary horn account for 0.0013% to 0.00067% of all pregnancies. Such pregnancies are non-viable and pose major risks to the mother. Without early detection and management, maternal mortality rates can be as high as 88% due to rupture.
Case Description:
A 22-year-old G1P0 female at 7 weeks gestation presented to the emergency department with abdominal pain for 3 weeks. A transvaginal ultrasound (TVUS) was performed and a fetal pole with cardiac activity was seen in the right adnexa, suspicious for ectopic pregnancy. She had an unremarkable TVUS 1 year ago. A diagnostic laparoscopy was performed for presumed treatment of ectopic pregnancy. During the procedure, patient was found to have a right non-communicating rudimentary uterine horn with pregnancy noted inside. The left horn was connected to the cervix and otherwise normal. Intraoperatively, the right ureter was not identified. Due to high risk of rupture, the rudimentary right horn with pregnancy and the right fallopian tube were resected. A postoperative CT urogram revealed a solitary renal kidney and single left ureter.
Clinical Significance:
The high mortality rate of ruptured NCRH pregnancies highlights the importance of early detection and proper management of such pregnancies. Mullerian duct anomalies are usually detected with ultrasound or magnetic resonance imaging prior to conception. In this case, the NRCH was formerly unknown and treated as an ectopic pregnancy with fetal cardiac activity. The complete resection of the rudimentary horn with pregnancy and fallopian tube proved to be an appropriate management for this emergent situation.
Conclusion:
In emergent situations of an undetected NRCH until pregnancy, resection of rudimentary horn with ipsilateral fallopian tube is not only therapeutic, but also preventative for potential future ectopic pregnancies
Multiplexed High-Resolution Imaging Approach to Decipher the Cellular Heterogeneity of the Kidney and its Alteration in Kidney Disease and Nephrolithiasis
Indiana University-Purdue University Indianapolis (IUPUI)Kidney disease and nephrolithiasis both present a major burden on the health care system in the US and worldwide. The cellular and molecular events governing the pathogenesis of these diseases are not fully understood. We propose that defining the cellular heterogeneity and niches in human and mouse kidney tissue specimens from controls and various models of renal disease could provide unique insights into the molecular pathogenesis. For that purpose, a multiplexed fluorescence imaging approach using co-detection by Indexing (CODEX) was used, using a panel of 33 and 38 markers for mouse and human kidney tissues, respectively. A customized computational analytical pipeline was developed and applied to the imaging data using unsupervised and/or semi-supervised machine learning and statistical approaches. The goal was to identify various cell populations present within the tissues, as well as identify unique cellular niches that may be altered with disease and/or injury. In mice, we examined disease models of acute kidney injury (AKI) and in human tissues we analyzed specimens from patients with AKI, IgA nephropathy, chronic kidney disease, systemic lupus erythematosus, and nephrolithiasis. In both mice and humans, the disease and reference samples show similar broad cell populations for the main segments of the nephron, endothelium, as well as similar groups of immune cells, such as resident macrophages and neutrophils. When comparing between health and disease, however, a change in the distribution of few sub-populations occurred. For example, in human kidney tissues, the abundance and distribution of a subpopulation of proximal tubules positive for THY1 (a marker of differentiation and repair), was markedly reduced with disease. Changes observed in mouse tissues included shifts in the immune cell population types and niches with disease. We propose that our analytical workflow and the observed changes in situ will play an important role in deciphering the pathogenesis of kidney disease
'A' is for ... Jane Austen (1775-1817)
Jane Austen (JA), English novelist and astute observer of human conduct and character, lived a quiet and all-too-brief life, producing merely six completed novels, several compositions of ‘Juvenilia,’ many brief historical sketches, and thousands of letters, mostly to her sister who destroyed 2/3 of them before her own death. Nevertheless, the products of JA’s pen remain respected, even beloved, more than 200 years after her death. ... JA is often referred to as a ‘moral’ writer, a writer concerned with how a person achieves or retrieves goodness in life, a focus some consider the very essence of good literature. ... JA’s expertise in character study and moral dilemma resolution shows us how to apply, to ourselves, the same expertise in understanding our personal conscience
An Ethical Responsibility? Research Access to Unique Manuscripts in the Custody of Private Collectors
Asks if manuscripts collectors have ethical responsibilities to make the unique materials in their possession available to researchers. Gives a case study of an historical record in private hands kept inaccessible to a researcher
Genetic Dissection of Chlamydia spp. Determinants of Tissue Tropism, Stress Response and Nutrient Acquisition
Indiana University-Purdue University Indianapolis (IUPUI)Chlamydia trachomatis (CT) is an obligate intracellular bacterium that transitions
between two distinct morphological forms during its complex developmental cycle.
During the intracellular portion of its developmental cycle, CT multiplies, evades host
immunity, and acquires nutrients. CT is the causative agent of chlamydia, the most
common bacterial sexually transmitted disease in the US. CT infection sometimes elicits
a robust host immune response which drives most chlamydia-associated pathology.
Chlamydia outcomes include urethritis in men and women, cervicitis in women, as well
as severe complications including pelvic inflammatory disease and ectopic pregnancies in
women and epididymitis in men. Sexually transmitted CT strains can also colonize
multiple tissues in their hosts, apart from urogenital organs. For example, CT can infect
cells of the gastrointestinal (GI) tract. Unlike urogenital infection, GI CT usually does not
elicit inflammatory pathology. My goal was to identify genes that are central to CT
pathogenesis. In one project, I characterized CTL0225, and showed that it is an amino
acid transporter that helps CT acquire essential nutrients from the host cell. In another
project, I identified a protease that helps CT survive stress, such as exposure to high
temperature. I also found evidence that this protease plays a crucial role in the transition
between morphological forms during CT development. Finally, I identified several novel
genes that may contribute to CT tissue tropism using a genetic screen. Overall, I have identified and characterized several new CT factors that mediate the survival and
virulence of this important pathogen.2023-09-0
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