74,133 research outputs found

    Nanocomposite colloids prepared by the Ouzo effect

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    Engineered nanoparticles have emerged as new types of materials for a wide range of applications from therapeutics to energy. Still, fabricating nanomaterials presenting complex inner morphologies and shapes in a simple manner remains a great challenge. Herein, we report the template‐free one‐pot continuous gradient nanoprecipitation of different types of non‐compatible polymers to spontaneously form nanostructured particles. The continuous addition of antisolvent induces precipitation and (re)organization of polymer chains at the forming particle interface, ultimately and naturally developing complex inner morphologies and shapes while particle grows. This low‐energy‐cost bottom‐up assembly approach applies to various functional polymers, possibly embedded with metal nanoparticles, for continuous growth into well‐organized nanoparticles. UV crosslinking of the particles and core removal allows both confirming the building process and leading to hollow or multivoid nanomaterials

    Villemain, Abel-François

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    RĂ©compenses et punitions, peut-on s'en passer ?

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    International audienc

    Potential of Germano-phosphosilicate Single Mode Optical Fibers for Dosimetry

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    International audienc

    Les actrices méconnues de la Réforme anglaise

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    International audienc

    Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

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    International audienceInfection and inflammation are two key features to consider to avoid septic or aseptic loosening of bone-implanted biomaterials. In this context, various approaches to fine-tune the biomaterial's properties have been studied in order to modulate the crosstalk between immune and skeletal cells. Cation-doping strategies for tuning of calcium phosphates properties has been evidenced as a promising way to control the biomaterial-induced inflammatory process, and thus improving their osteoimmunomodulatory properties. Copper(II) ions are recognized for their antibacterial potential, but the literature on their impact on particulate material-induced acute inflammation is scarce. We synthesized copper(II) ions-doped biphasic calcium phosphate (BCP), intended to exhibit osteoimmunomodulatory properties. We addressed in vitro, for the first time, the inflammatory response of human primary polymorphonuclear neutrophils (PMNs) to copper(II) ions-doped or undoped (BCP) powders, synthesized by an original and robust wet method, in the presence or absence of LPS as a costimulant to mimic an infectious environment. ELISA and zymography allowed us to evidence, in vitro, a specific increase in IL-8 and GRO-α secretion but not MIP-1ÎČ, TNF-α, or MMP-9, by PMNs. To assess in vivo relevance of these findings, we used a mouse air pouch model. Thanks to flow cytometry analysis, we highlighted an increased PMN recruitment with the copper(II) ions-doped samples compared to undoped samples. The immunomodulatory effect of copper(II) ions-doped BCP powders and the consequent induced moderate level of inflammation may promote bacterial clearance by PMNs in addition to the antimicrobial potential of the material. Copper(II) doping provides new insights into calcium phosphate (CaP)-based biomaterials for prosthesis coating or bone reconstruction by effectively modulating the inflammatory environment

    Paresse, noblesse et identité sociale dans les Conversations de Madeleine de Scudéry

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    International audienceIn Madeleine de Scudery’s Conversations, laziness brings to light social and political dynamics and may appear as an ambivalent response to political change.Dans les Conversations de Madeleine de ScudĂ©ry, la paresse met en Ă©vidence des dynamiques sociales et politiques et peut apparaĂźtre comme une rĂ©action ambivalente aux changements politiques

    Right-censored models by the expectile method

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    Based on the expectile loss function and the adaptive LASSO penalty, the paper proposes and studies the estimation methods for the accelerated failure time (AFT) model. In this approach, we need to estimate the survival function of the censoring variable by the Kaplan-Meier estimator. The AFT model parameters are first estimated by the expectile method and afterwards, when the number of explanatory variables can be large, by the adaptive LASSO expectile method which directly carries out the automatic selection of variables. We also obtain the convergence rate and asymptotic normality for the two estimators, while showing the sparsity property for the censored adaptive LASSO expectile estimator. A numerical study using Monte Carlo simulations confirms the theoretical results and demonstrates the competitive performance of the two proposed estimators. The usefulness of these estimators is illustrated by applying them to three survival data sets

    Where is the Phoenician harbour of Tyre?

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    https://archeorient.hypotheses.org/26907The renowned Phoenician city of Tyre (Lebanon) is one of the finest examples of major changes triggered by theconstruction of a causeway affecting the development of its harbours. Building sustainable ports along coastlines isa difficult endeavour because coastlines are among the most rapidly changing landscapes on Earth. This challenge isfaced worldwide today. Besides, the erection of coastal structures alters coastal dynamics in such a way that newstructures tend to affect earlier constructions. The study of ancient harbours shows that it has been a naggingproblem in coastal management since Antiquity. Investigating ancient cases is interesting because it provides moretime depth into these changes than the modern cases, owing to the centuries of coastal changes that have elapsedsince the structures started to alter their environment
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