564 research outputs found

    Staphylococcus aureus の Sulfamethoxazole-trimethoprim 耐性small colony variants に関する研究

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    東北医科薬科大学令和元年

    発表論文要旨

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    ハクトウオウの化学成分(第1報) Hederagonic Acidの同定並びに立体配座について

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    From the roots of Pulsatilla chinensis (BUNGE) REGEL (Ranunculaceae),hederagonic acid (1) was isolated and identified on the basis of spectral data.Compound 1 has been isolated from the roots of this plant for the first time.Some correlations in the HMBC and NOESY spectra of compound 1 suggested the existence of a conformational equilibrium on the C23-hydroxyl group

    CONTENTS

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    薬物療法に関わる患者評価指標 ── 臨床薬剤学的にみる現状と課題──

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    Pharmacists have only recently become deeply involved in the pharmacotherapy of individual patients in Japan.Recognition of the need for pharmacists to conduct physical assessments of patients is growing, and pharmacists seem to have gradually started conducting quantitative evaluations of patients. However, pharmacists must base their evaluations on indices that have been developed for use in clinical medicine; therefore, the pharmaceutical perspective is missing in many cases.This study was conducted with the aim of establishing appropriate indices for evaluating patients from pharmaceutical viewpoints.In an individual patient, many factors must be considered when determining the optimal administration of a drug.Patient-related factors include“the state of the patient”and“the patient s way of thinking”.Pharmacy-related factors include“the acquisition and use of the medicine”and“the properties of the medicine”.This article evaluates the currently available pharmacy-related indices for assessing“the state of the patient”.Choosing the appropriate dosage for administration is often based on experience, and very few objective metrics can be found in the published literature.Therefore, it is very important to ensure that all medical staff use the same indices to evaluate patients from pharmaceutical viewpoints in order to ensure safe and effective pharmacotherapy

    細胞ELISAを用いたCandida属酵母表層抗原の検出

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    We conducted cell-enzyme linked- immunosorbent assay (Cell-ELISA) to detect the specific surface antigens of Candidaspecies strain cells using factor sera from commercially available serum factor kit (Candida Check).The use of poly-L-lysine and glutaraldehyde in the Cell-ELISA was very useful to stick the yeast cells (antigens) to microtiterplate.The Cell-ELISA detercted more clearly the surface antigens compared with the commercial slide agglutination test.We showed that the Cell-ELISA might detect qualitatively and/or qualitatively the mannan of the yeast surface by using antibodies with the mannan structure specificity

    表紙、目次、奥付

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    α1,6-Fucosyltransferase Is Required for Liver Regeneration and Chemical Induced Hepatocarcinogenesis

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    東北薬科大学平成26年
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