Arithmeticity of Orbifold Generalised Triangle Groups

Maclachlan and Martin have proved that only finitely many arithmetic Kleinian groups can be generated by 2 elliptic elements, and have classified these groups in the non-cocompact case. Here, we investigate the cocompact case, restricting to a class of generalisedtrianglegroups considered by Jones and Reid which arise as the fundamental groups of hyperbolic 3-dimensional orbifolds. We obtain 21 arithmetic groups and provide a description of the corresponding orbifolds

Specimen dimensions influence the measurement of material properties in tendon fascicles

Stress, strain and modulus are regularly used to characterize material properties of tissue samples. However, when comparing results from different studies it is evident the reported material properties, particularly failure strains, vary hugely. The aim of our study was to characterize how and why specimen length and cross-sectional area (CSA) appear to influence failure stress, strain and modulus in fascicles from two functionally different tendons. Fascicles were dissected from five rat tails and five bovine foot extensors, their diameters determined by a laser micrometer, and loaded to failure at a range of grip-to-grip lengths. Strain to failure significantly decreased with increasing in specimen length in both rat and bovine fascicles, while modulus increased. Specimen length did not influence failure stress in rat tail fascicles, although in bovine fascicles it was significantly lower in the longer 40 mm specimens compared to 5 and 10 mm specimens. The variations in failure strain and modulus with sample length could be predominantly explained by end-effects. However, it was also evident that strain fields along the sample length were highly variable and notably larger towards the ends of the sample than the mid-section even at distances in excess of 5 mm from the gripping points. Failure strain, stress and modulus correlated significantly with CSA at certain specimen lengths. Our findings have implications for the mechanical testing of tendon tissue: while it is not always possible to control for fascicle length and/or CSA, these parameters have to be taken into account when comparing samples of different dimensions

"Getting sicker quicker": does living in a more deprived neighbourhood mean your health deteriorates faster?

Data from the longitudinal West of Scotland Twenty-07 Study: Health in the Community was used to examine whether, over a 20 year period, the self-reported health of people living in deprived areas became poorer faster compared to those living in more affluent areas. Three cohorts (born in the early 1930s, 1950s and 1970s) are included, covering 60 years of the life span. Using multilevel growth curve models, a 40% probability of reporting poor health was predicted among residents of more deprived areas at an earlier age (66) compared to those living in more affluent areas (83). Wider area differences were seen for men than for women. Our findings indicate that attempts to reduce area differences in health should start young but also continue throughout the lifespan

Regime switching volatility calibration by the Baum-Welch method

Regime switching volatility models provide a tractable method of modelling stochastic volatility. Currently the most popular method of regime switching calibration is the Hamilton filter. We propose using the Baum-Welch algorithm, an established technique from Engineering, to calibrate regime switching models instead. We demonstrate the Baum-Welch algorithm and discuss the significant advantages that it provides compared to the Hamilton filter. We provide computational results of calibrating and comparing the performance of the Baum-Welch and the Hamilton filter to S&P 500 and Nikkei 225 data, examining their performance in and out of sample

A chain theorem for 4-connected matroids

For the abstract of this paper, please see the PDF file

Robust variance-constrained H∞ control for stochastic systems with multiplicative noises

This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Elsevier Ltd.In this paper, the robust variance-constrained H∞ control problem is considered for uncertain stochastic systems with multiplicative noises. The norm-bounded parametric uncertainties enter into both the system and output matrices. The purpose of the problem is to design a state feedback controller such that, for all admissible parameter uncertainties, (1) the closed-loop system is exponentially mean-square quadratically stable; (2) the individual steady-state variance satisfies given upper bound constraints; and (3) the prescribed noise attenuation level is guaranteed in an H∞ sense with respect to the additive noise disturbances. A general framework is established to solve the addressed multiobjective problem by using a linear matrix inequality (LMI) approach, where the required stability, the H∞ characterization and variance constraints are all easily enforced. Within such a framework, two additional optimization problems are formulated: one is to optimize the H∞ performance, and the other is to minimize the weighted sum of the system state variances. A numerical example is provided to illustrate the effectiveness of the proposed design algorithm.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grant GR/S27658/01, the Nuffield Foundation of the UK under Grant NAL/00630/G, and the Alexander von Humboldt Foundation of Germany

Rational S^1-equivariant elliptic cohomology

For each elliptic curve A over the rational numbers we construct a 2-periodic S^1-equivariant cohomology theory E whose cohomology ring is the sheaf cohomology of A; the homology of the sphere of the representation z^n is the cohomology of the divisor A(n) of points with order dividing n. The construction proceeds by using the algebraic models of the author's AMS Memoir ``Rational S^1 equivariant homotopy theory.'' and is natural and explicit in terms of sheaves of functions on A. This is Version 5.2 of a paper of long genesis (this should be the final version). The following additional topics were first added in the Fourth Edition: (a) periodicity and differentials treated (b) dependence on coordinate (c) relationship with Grojnowksi's construction and, most importantly, (d) equivalence between a derived category of O_A-modules and a derived category of EA-modules. The Fifth Edition included (e) the Hasse square and (f) explanation of how to calculate maps of EA-module spectra

Fiber depolymerization

Depolymerization is, by definition, a crucial process in the reversible assembly of various biopolymers. It may also be an important factor in the pathology of sickle cell disease. If sickle hemoglobin fibers fail to depolymerize fully during passage through the lungs then they will reintroduce aggregates into the systemic circulation and eliminate or shorten the protective delay (nucleation) time for the subsequent growth of fibers. We study how depolymerization depends on the rates of end- and side-depolymerization, kend and kside, which are, respectively, the rates at which fiber length is lost at each end and the rate at which new breaks appear per unit fiber length. We present both an analytic mean field theory and supporting simulations showing that the characteristic fiber depolymerization time View the MathML source depends on both rates, but not on the fiber length L, in a large intermediate regime 1 much less-than ksideL2/kend much less-than (L/d)2, with d the fiber diameter. We present new experimental data which confirms that both mechanisms are important and shows how the rate of side depolymerization depends strongly on the concentration of CO, acting as a proxy for oxygen. Our theory remains rather general and could be applied to the depolymerization of an entire class of linear aggregates, not just sickle hemoglobin fibers

Non-diagonal charged lepton mass matrix and non-zero θ13\theta_{13}

Assuming that the neutrino mass matrix is diagonalized by the tribimaximal mixing matrix, we explore the textures for the charged lepton mass matrix that render an $U_{PMNS}$ lepton mixing matrix consistent with data. In particular we are interested in finding the textures with the maximum number of zeros. We explore the cases of real matrices with three and four zeros and find that only ten matrices with three zeros provide solutions in agreement with data. We present the successful Yukawa textures including the relative sizes of their non-zero entries as well as some new and interesting relations among the entries of these textures in terms of the charged lepton masses. We also show that these relations can be obtained directly from a parametrization of the charged lepton mixing matrix $U_l$.Comment: 16 pages, two figures. A parametrization of the mixing matrix $U_l$ was introduced to explain observed patterns in textures. References adde

Domain-domain interactions in Filamin A (16-23) impose a hierarchy of unfolding forces

The quaternary structure of Filamin A (FLNa) 16-23 was recently shown to exhibit multiple domain-domain interactions that lead to a propeller-like construction. Here we present single molecule force spectroscopy experiments to show a wide variety of mechanical responses of this molecule and compare it with its linear counterpart FLNa 1-8. The compact structure of FLNa 16-23 leads to a broad distribution of rupture forces and end-to-end lengths in the force-extension mode and multiple unraveling timescales in the force-clamp mode. Moreover, a subset of force-extension trajectories reveals a mechanical hierarchy in which the rupture of domain-domain interactions at high forces (200 pN) liberates the unfolding of individual domains at low forces (100 pN). This mechanism may also explain the order of magnitude difference in the rates of the biexponential fits to the distribution of unfolding dwell times under force-clamp. Overall, FLNa 16-23 under a force of 100 pN is more compliant than the linear FLNa 1-8. Since a physiological role of FLNa is to crosslink actin filaments, this range of responses allows it to accommodate a broad spectrum of forces exerted by the cell and its environment