32,941 research outputs found

    Small newborns in post-conflict Northern Uganda: Burden and interventions for improved outcomes

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    Introduction: A small newborn can be the result of either a low birthweight (LBW), or a preterm birth (PB), or both. LBW can be due to either a preterm appropriate-for gestational-age (preterm-AGA), or a term small-for-gestational age (term-SGA) or intrauterine growth restriction (IUGR). An IUGR is a limited in-utero foetal growth rates or foetal weight < 10th percentile. Small newborns have an increased risk of dying, particularly in low-resource settings. We set out to assess the burden, the modifiable risk factors and health outcomes of small newborns in the post-conflict Northern Ugandan district of Lira. In addition, we studied the use of video-debriefing when training health staff in Helping Babies Breathe. Subjects and methods: In 2018-19, we conducted a community-based cohort study on 1556 mother-infant dyads, nested within a cluster randomized trial. In our cohort study, we estimated the incidence and risk factors for LBW and PB and the association of LBW with severe outcomes. We explored the prevalence of and factors associated with neonatal hypoglycaemia, as well as any association between neonatal death and hypoglycaemia. In addition, we conducted a cluster randomized trial to compare Helping Babies Breathe (HBB) training in combination with video debriefing to the traditional HBB training alone on the attainment and retention of health worker neonatal resuscitation competency. Results: The incidence of LBW and PB in our cohort was lower than the global estimates, 7.3% and 5.0%, respectively. Intermittent preventive treatment for malaria was associated with a reduced risk of LBW. HIV infection was associated with an increased risk of both LBW and PB, while maternal formal education (schooling) of Ôëą7 years was associated with a reduced risk of LBW and PB. The proportions of neonatal deaths were many-folds higher among LBW infants compared to their non-LBW counterparts. The proportion of neonatal deaths among LBW was 103/1000 live births compared to 5/1000 among the non-LBW. The prevalence of neonatal hypoglycaemia in our cohort was 2.5%. LBW and PB each independently were associated with an increased risk of neonatal hypoglycaemia. Neonatal hypoglycaemia was associated with an increased risk of hospitalisation and severe outcomes. We demonstrated that neonatal resuscitation training with video debriefing, improved competence attainment and retention among health workers, compared to traditional HBB training alone. Conclusion: In northern Uganda, small infants still have a many-fold higher risk of dying compared to normal infants. In addition, small infants are also at more risk of neonatal hypoglycaemia compared to normal infants. Efforts are needed to secure essential newborn care, should we reach the target of Sustainable Development Goal number 3.2 of reducing infant mortality to less than 12/1000 live births by 2030

    Multiple functions and regulatory network of miR-150 in B lymphocyte-related diseases

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    MicroRNAs (miRNAs) play vital roles in the post-transcriptional regulation of gene expression. Previous studies have shown that miR-150 is a crucial regulator of B cell proliferation, differentiation, metabolism, and apoptosis. miR-150 regulates the immune homeostasis during the development of obesity and is aberrantly expressed in multiple B-cell-related malignant tumors. Additionally, the altered expression of MIR-150 is a diagnostic biomarker of various autoimmune diseases. Furthermore, exosome-derived miR-150 is considered as prognostic tool in B cell lymphoma, autoimmune diseases and immune-mediated disorders, suggesting miR-150 plays a vital role in disease onset and progression. In this review, we summarized the miR-150-dependent regulation of B cell function in B cell-related immune diseases

    Annual SHOT Report 2018

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    SHOT is affiliated to the Royal College of PathologistsAll NHS organisations must move away from a blame culture towards a just and learning culture. All clinical and laboratory staff should be encouraged to become familiar with human factors and ergonomics concepts. All transfusion decisions must be made after carefully assessing the risks and benefits of transfusion therapy. Collaboration and co-ordination among staff is vital

    Hypoglycemia: A Mimic of Global Ischemic Injury

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    Food security status in children hospitalized in pediatrics and its association with malnutrition

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    La seguridad alimentaria es un determinante de salud y nutrici├│n, pues ÔÇťtodas las personas tienen, en todo momento, acceso f├şsico y econ├│mico a suficientes alimentos inocuos y nutritivos para satisfacer sus necesidades diet├ęticas y preferencias alimenticias para una vida activa y sanaÔÇŁ, el objetivo de este estudio es establecer el estado de seguridad alimentaria de los ni├▒os que son hospitalizados los servicios de Pediatr├şa y determinar si existe relaci├│n son su estado de nutrici├│n. Se realiz├│ una revisi├│n bibliogr├ífica sistem├ítica en bases de datos y bibliotecas electr├│nicas, que incluy├│ art├şculos en ingl├ęs y espa├▒ol del 2022 que, contuvieran los t├│picos de inter├ęs. Se realiz├│ una descripci├│n detallada de los trastornos de seguridad alimentaria en ni├▒os hospitalizados en pediatr├şa y su asociaci├│n con malnutrici├│n, obteniendo como resultados varios factores, como lo son pacientes que no son atendidos en ambientes hospitalarios y no se contabilizan, pacientes que son diagnosticados, pero no son censados o pacientes que son atendidos en instituciones, pero no son diagnosticados al inicio, estado de seguridad alimentaria en el hogar, estado nutricional; Los ni├▒os ten├şan desnutrici├│n en un 17%, sobrepeso 13%; los mayores porcentajes de ni├▒os malnutridos estuvieron en hogares con inseguridad alimentaria; sin embargo, en ning├║n caso de los revisado, se demostr├│ asociaci├│n estad├şsticamente significativa, de tal forma se concluye que, pese a los altos porcentajes de Inseguridad alimentaria, no se demostr├│ asociaci├│n significativa con malnutrici├│n.Food security is a determinant of health and nutrition, since "all people have, at all times, physical and economic access to sufficient safe and nutritious food to meet their dietary needs and food preferences for an active and healthy life", the objective of this study is to establish the food safety status of children who are hospitalized in Pediatric services and determine if there is a relationship with their nutritional status. A systematic bibliographic review was carried out in databases and electronic libraries, which included articles in English and Spanish from 2022 that contained the topics of interest. A detailed description of food safety disorders in children hospitalized in pediatrics and their association with malnutrition was made, obtaining as results several factors, such as patients who are not treated in hospital environments and are not counted, patients who are diagnosed, but They are not registered or patients who are cared for in institutions, but are not diagnosed at the beginning, food security status at home, nutritional status; The children had malnutrition in 17%, overweight 13%; the highest percentages of malnourished children were in households with food insecurity; however, in none of the cases reviewed was a statistically significant association demonstrated, thus it is concluded that, despite the high percentages of food insecurity, no significant association with malnutrition was demonstrated

    Anu├írio cient├şfico da Escola Superior de Tecnologia da Sa├║de de Lisboa - 2021

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    ├ë com grande prazer que apresentamos a mais recente edi├ž├úo (a 11.┬¬) do Anu├írio Cient├şfico da Escola Superior de Tecnologia da Sa├║de de Lisboa. Como institui├ž├úo de ensino superior, temos o compromisso de promover e incentivar a pesquisa cient├şfica em todas as ├íreas do conhecimento que contemplam a nossa miss├úo. Esta publica├ž├úo tem como objetivo divulgar toda a produ├ž├úo cient├şfica desenvolvida pelos Professores, Investigadores, Estudantes e Pessoal n├úo Docente da ESTeSL durante 2021. Este Anu├írio ├ę, assim, o reflexo do trabalho ├írduo e dedicado da nossa comunidade, que se empenhou na produ├ž├úo de conte├║do cient├şfico de elevada qualidade e partilhada com a Sociedade na forma de livros, cap├ştulos de livros, artigos publicados em revistas nacionais e internacionais, resumos de comunica├ž├Áes orais e p├│steres, bem como resultado dos trabalhos de 1┬║ e 2┬║ ciclo. Com isto, o conte├║do desta publica├ž├úo abrange uma ampla variedade de t├│picos, desde temas mais fundamentais at├ę estudos de aplica├ž├úo pr├ítica em contextos espec├şficos de Sa├║de, refletindo desta forma a pluralidade e diversidade de ├íreas que definem, e tornam ├║nica, a ESTeSL. Acreditamos que a investiga├ž├úo e pesquisa cient├şfica ├ę um eixo fundamental para o desenvolvimento da sociedade e ├ę por isso que incentivamos os nossos estudantes a envolverem-se em atividades de pesquisa e pr├ítica baseada na evid├¬ncia desde o in├şcio dos seus estudos na ESTeSL. Esta publica├ž├úo ├ę um exemplo do sucesso desses esfor├žos, sendo a maior de sempre, o que faz com que estejamos muito orgulhosos em partilhar os resultados e descobertas dos nossos investigadores com a comunidade cient├şfica e o p├║blico em geral. Esperamos que este Anu├írio inspire e motive outros estudantes, profissionais de sa├║de, professores e outros colaboradores a continuarem a explorar novas ideias e contribuir para o avan├žo da ci├¬ncia e da tecnologia no corpo de conhecimento pr├│prio das ├íreas que comp├Áe a ESTeSL. Agradecemos a todos os envolvidos na produ├ž├úo deste anu├írio e desejamos uma leitura inspiradora e agrad├ível.info:eu-repo/semantics/publishedVersio

    Cardiomiopatia Hipertr├│fica felina: a correla├ž├úo entre a sintomatologia e os achados ecocardiograficos

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    A presente disserta├ž├úo est├í dividida em dois cap├ştulos principais. No primeiro encontra-se descrito uma revis├úo bibliogr├ífica da doen├ža cardiomiopatia hipertr├│fica felina, no segundo o estudo desenvolvido pela estagi├íria. A aluna, durante o est├ígio curricular, recolheu 15 casos cl├şnicos que atrav├ęs de uma an├ílise de frequ├¬ncias absolutas e relativas, da correla├ž├úo de pearson e do teste anova, permitiu averiguar a correla├ž├úo existente entre os sinais cl├şnicos e os achados ecocardiogr├íficos, assim como o paralelismo entre as informa├ž├Áes recolhidas e a literatura. O destaque da presente disserta├ž├úo consistiu na diverg├¬ncia com os dados bibliogr├íficos, nomeadamente, no que confere ├á preval├¬ncia racial e ├á presen├ža de CMH obstrutiva em animais assintom├íticos. No que se refere as vari├íveis, foi not├│ria a correla├ž├úo entre os sinais cl├şnicos mais graves e os par├ómetros ecocardiogr├íficos mais severos; Abstract: Feline hypertrophic cardiomyopathy - The present dissertation is divided into two main chapters. The first describes a bibliographical review of the disease feline hypertrophic cardiomyopathy, the second the study developed by the intern. The student, during the curricular internship, collected 15 clinical cases that, through an analysis of absolute and relative frequencies, the Pearson correlation and the Anova test, allowed to verify the correlation between the clinical signs and the echocardiographic findings and the parallelism between the information collected and the literature. The highlights of the present work was the incompatibility between the available literature and the data regarding (racial prevalence, echocardiographic findings, and presence of obstructive hypertrophic cardiomyopathy), as well as the correlation between the most severe clinical signs and the most severe echocardiographic parameters

    Oral microbiome correlates with selected clinical biomarkers in individuals with no significant systemic disease

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    The oral microbiome is an important component of the microbiome in the human body. Although the association of the oral microbiome with various diseases, including periodontitis and cancer, has been reported, information on how the oral microbiome is related to health-related indicators in healthy populations is still insufficient. In this study, we examined the associations of the oral microbiome with 15 metabolic and 19 complete blood count (CBC)-based markers in 692 healthy Korean individuals. The richness of the oral microbiome was associated with four CBC markers and one metabolic marker. Compositional variation in the oral microbiome was significantly explained by four markers: fasting glucose, fasting insulin, white blood cell count, and total leukocyte count. Furthermore, we found that these biomarkers were associated with the relative abundances of numerous microbial genera, such as Treponema, TG5, and Tannerella. By identifying the relationship between the oral microbiome and clinical biomarkers in a healthy population, our study presents a direction for future studies on oral microbiome-based diagnosis and interventions

    MATURE-HEALTH: HEALTH Recommender System for MAndatory FeaTURE choices

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    Balancing electrolytes is utmost important and essential for appropriate functioning of organs in human body as electrolytes imbalance can be an indication of the development of underlying pathophysiology. Efficient monitoring of electrolytes imbalance not only can increase the chances of early detection of disease, but also prevents the further deterioration of the health by strictly following nutrient controlled diet for balancing the electrolytes post disease detection. In this research, a recommender system MATURE Health is proposed and implemented, which predicts the imbalance of mandatory electrolytes and other substances presented in blood and recommends the food items with the balanced nutrients to avoid occurrence of the electrolytes imbalance. The proposed model takes user most recent laboratory results and daily food intake into account to predict the electrolytes imbalance. MATURE Health relies on MATURE Food algorithm to recommend food items as latter recommends only those food items that satisfy all mandatory nutrient requirements while also considering user past food preferences. To validate the proposed method, particularly sodium, potassium, and BUN levels have been predicted with prediction algorithm, Random Forest, for dialysis patients using their laboratory reports history and daily food intake. And, the proposed model demonstrates 99.53 percent, 96.94 percent and 95.35 percent accuracy for Sodium, Potassium, and BUN respectively. MATURE Health is a novel health recommender system that implements machine learning models to predict the imbalance of mandatory electrolytes and other substances in the blood and recommends the food items which contain the required amount of the nutrients that prevent or at least reduce the risk of the electrolytes imbalance.Comment: Author version of the pape
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