176 research outputs found

    Szybka diagnostyka patomorfologiczna i molekularna chorych na raka p艂uca na podstawie techniki telepatologii

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    Telepathology is an emerging form of diagnostic process introducing digitalization of slides prepared from formalin-fixed paraffin-embedded materials and stained cytological smears. The use of whole slide imaging (WSI) systems could accelerate and improve the diagnosis of malignant neoplasms without the need of on-site pathologist or transporting diagnostic material in-between different locations. The implementation of endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS) with fine needle aspiration (FNA) in diagnostic process of advanced lung cancer creates a new field for telepathology utilization. In selected patients, pathomorphological and genetic diagnosis may take less than a week and therapeutic decisions can be made in a short time. There are several important issues that concern the use of telepathology and WSI in everyday clinical environment. This short review presents the pros and cons of this technology and its applicability in rapid diagnosis of lung cancer, its utilization in connection with novel sampling methods and molecular analysis.Telepatologia to nowa forma procesu diagnostycznego wprowadzaj膮ca cyfryzacj臋 preparat贸w przygotowanych z bloczk贸w parafinowych lub wybarwionych rozmaz贸w cytologicznych. Wykorzystanie systemu skanowania ca艂ych preparat贸w mo偶e polepszy膰 i znacz膮co przyspieszy膰 diagnostyk臋 nowotwor贸w z艂o艣liwych bez wymaganej obecno艣ci patomorfologa w miejscu wykonywania diagnostyki oraz bez potrzeby transportowania pobranego materia艂u pomi臋dzy r贸偶nymi lokalizacjami. Wprowadzenie biopsji aspiracyjnej cienkoig艂owej (FNA) przeprowadzanej pod kontrol膮 przezoskrzelowego lub przezprze艂ykowego USG (EBUS lub EUS) do procesu diagnostycznego zaawansowanego raka p艂uca tworzy nowe pole do zastosowania telepatologii. U wybranych chorych diagnoza patomorfologiczna i genetyczna mo偶e trwa膰 poni偶ej tygodnia, a decyzje terapeutyczne mog膮 zosta膰 podj臋te w kr贸tkim czasie. Istnieje kilka istotnych kwestii zwi膮zanych z wykorzystaniem telepatologii oraz skanowania ca艂ych preparat贸w w codziennej praktyce klinicznej. Ten kr贸tki przegl膮d ma na celu przybli偶enie wad i zalet opisanej technologii i ich mo偶liwo艣ci wykorzystania w szybkiej diagnostyce raka p艂uca w po艂膮czeniu z nowoczesnymi metodami pobierania materia艂u i konieczno艣ci膮 prowadzenia diagnostyki genetycznej

    The future of laboratory medicine - A 2014 perspective.

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    Predicting the future is a difficult task. Not surprisingly, there are many examples and assumptions that have proved to be wrong. This review surveys the many predictions, beginning in 1887, about the future of laboratory medicine and its sub-specialties such as clinical chemistry and molecular pathology. It provides a commentary on the accuracy of the predictions and offers opinions on emerging technologies, economic factors and social developments that may play a role in shaping the future of laboratory medicine

    Is telepathology worth being developed?

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    In pathology, similarly to other branches of medicine, and in particular in the field of visualisation techniques, the use of image transmission via the Internet for diagnostic or consulting purposes is being introduced. One of the reasons for this is the limited number of specialists. Currently, three basic applications of this technique can be distinguished: telediagnostics, teleconsultations and teleconferences.In contrast to teleradiology where the basic subject of analysis is the image obtained by various visualisation techniques 鈥 in pathology, the basis is tissue or cell analysis. The evaluation of such material should be from the start in the hands of pathomorphologists. The transmitted image of the performed histological preparation may not be fully representative of the lesion being examined (cancer). In modern oncological pathomorphology, it is very often necessary to use special techniques such as immunohistology or molecular biology techniques to determine theproper diagnosis. Performing such tests requires direct access to tissue or cytological material.Telepathology can be used as part of consultations between reference centres. Modern telepathology techniques allow the use of these methods for training purposes, including the interactive participation of trainees

    Digital pathology in clinical use: where are we now and what is holding us back?

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    Whole slide imaging is being used increasingly in research applications and in frozen section, consultation and external quality assurance practice. Digital pathology, when integrated with other digital tools such as barcoding, specimen tracking and digital dictation, can be integrated into the histopathology workflow, from specimen accession to report sign-out. These elements can bring about improvements in the safety, quality and efficiency of a histopathology department. The present paper reviews the evidence for these benefits. We then discuss the challenges of implementing a fully digital pathology workflow, including the regulatory environment, validation of whole slide imaging and the evidence for the design of a digital pathology workstation

    History and structures of telecommunication in pathology, focusing on open access platforms

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    <p>Abstract</p> <p>Background</p> <p>Telecommunication has matured to a broadly applied tool in diagnostic pathology.</p> <p>Technology and Systems</p> <p>Contemporary with the development of fast electronic communication lines (Integrated digital network services (ISDN), broad band connections, and fibre optics, as well as the digital imaging technology (digital camera), telecommunication in tissue - based diagnosis (telepathology) has matured. Open access (internet) and server - based communication have induced the development of specific medical information platforms, such as iPATH, UICC-TPCC (telepathology consultation centre of the Union International against Cancer), or the Armed Forces Institute of Pathology (AFIP) teleconsultation system. They have been closed, and are subject to be replaced by specific open access forums (Medical Electronic Expert Communication System (MECES) with embedded virtual slide (VS) technology). MECES uses php language, data base driven mySqL architecture, X/L-AMPP infrastructure, and browser friendly W3C conform standards.</p> <p>Experiences</p> <p>The server - based medical communication systems (AFIP, iPATH, UICC-TPCC) have been reported to be a useful and easy to handle tool for expert consultation. Correct sampling and evaluation of transmitted still images by experts reported revealed no or only minor differences to the original images and good practice of the involved experts. 尾 tests with the new generation medical expert consultation systems (MECES) revealed superior results in terms of performance, still image viewing, and system handling, especially as this is closely related to the use of so - called social forums (facebook, youtube, etc.).</p> <p>Benefits and Expectations</p> <p>In addition to the acknowledged advantages of the former established systems (assistance of pathologists working in developing countries, diagnosis confirmation, international information exchange, etc.), the new generation offers additional benefits such as acoustic information transfer, assistance in image screening, VS technology, and teaching in diagnostic sampling, judgement, and verification.</p

    Background

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    PROCEEDINGS A rich internet application for remote visualization and collaborative annotation of digital slides in histology and cytolog

    Histopathology: An Old Yet Important Technique in Modern Science

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    Histopathology is a scientific study of disease at the tissue and cellular levels. Despite an old practice, the histopathology reserved one of the substantial sections of disease studies, both and medical and veterinary field in the modern scientific era. During the current molecular age, some improvements have been made in this practice. The early modification in histopathology is the introduction of immunohistochemistry, which playing an incredible role in tumor diagnosis. The new developments, including digital pathology, multiplex immunohistochemistry, immunofluorescence, brain mapping, neuroimaging studies and artificial neuronal networking are emphasizing novel technologies and almost changed the previous ordinary diagnostic methods. The existing molecular pathobiology, was evolved mainly from biopsy and autopsy. Currently, the revolutions in molecular biology and in the technology of gene array have developed. The telepathology helping the society and deals with histopathological pictures. It is not far, when molecular techniques would be applied to the lesions prior to its paraffinizations, and the histopathological experts would previously recognize what to study in the sections. The productive move from a visual morphological explanation to obscure molecular science, may be delay, but ultimately be there. This chapter tries to express few of such characteristics of the histopathological practice which assured to be the fast progressing portion of the modern science

    Virtual slides in peer reviewed, open access medical publication

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    <p>Abstract</p> <p>Background</p> <p>Application of virtual slides (VS), the digitalization of complete glass slides, is in its infancy to be implemented in routine diagnostic surgical pathology and to issues that are related to tissue-based diagnosis, such as education and scientific publication.</p> <p>Approach</p> <p>Electronic publication in Pathology offers new features of scientific communication in pathology that cannot be obtained by conventional paper based journals. Most of these features are based upon completely open or partly directed interaction between the reader and the system that distributes the article. One of these interactions can be applied to microscopic images allowing the reader to navigate and magnify the presented images. VS and interactive Virtual Microscopy (VM) are a tool to increase the scientific value of microscopic images.</p> <p>Technology and Performance</p> <p>The open access journal Diagnostic Pathology <url>http://www.diagnosticpathology.org</url> has existed for about five years. It is a peer reviewed journal that publishes all types of scientific contributions, including original scientific work, case reports and review articles. In addition to digitized still images the authors of appropriate articles are requested to submit the underlying glass slides to an institution (DiagnomX.eu, and Leica.com) for digitalization and documentation. The images are stored in a separate image data bank which is adequately linked to the article. The normal review process is not involved. Both processes (peer review and VS acquisition) are performed contemporaneously in order to minimize a potential publication delay. VS are not provided with a DOI index (digital object identifier). The first articles that include VS were published in March 2011.</p> <p>Results and Perspectives</p> <p>Several logistic constraints had to be overcome until the first articles including VS could be published. Step by step an automated acquisition and distribution system had to be implemented to the corresponding article. The acceptance of VS by the reader is high as well as by the authors. Of specific value are the increased confidence to and reputation of authors as well as the presented information to the reader. Additional associated functions such as access to author-owned related image collections, reader-controlled automated image measurements and image transformations are in preparation.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1232133347629819</url>.</p
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