Apocrine hidrocystoma on the nipple: the first report in this unusual location

Apocrine hidrocystoma is a rare, benign, cystic tumor of the apocrine sweat glands. They are most commonly located around the eyes and may also be found on the scalp and neck. However, despite the fact that the nipple and areola contain numerous apocrine sweet glands, apocrine hydrocystomas have not been described previously in this area to the best of our knowledge. We report the first case of this cyst in this unsual location

Case of Eccrine hidrocystoma of the vulva

. Objective: Eccrine hidrocystomas are benign cystic lesions that are very rare; their presence on the vulva is extraordinarily rare. We present a woman with a solitary eccrine hidrocystoma of the vulva. Case: A 36-year-old woman presented with a six month history of an asymptomatic and enlarging blue-black lesion on the left labia. The histopathological diagnosis after excision was eccrine hidrocystoma. After removal, she had complete healing of the site and did not require any further intervention. Conclusions: Eccrine hidrocystomas are benign tumors. Their clinical presentation on the vulva can mimic other benign or malignant lesions, therefore biopsy and histological evaluation is necessary

Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report

A rare case of an apocrine tumor in the male perineal region is reported. A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male. The cystic lesion, measuring 3.5 × 5.0 cm in size, was lined by columnar or flattened epithelium with occasional apocrine features and supported by a basal myoepithelium lining. A mural nodule, measuring 1 × 1.5 cm in size, protruded into the cystic space and consisted of a solid proliferation of tubular glands with prominent apocrine secretion and basal myoepithelial cells. Immunohistochemical examination showed that the luminal cells were partially positive for gross cystic disease fluid protein 15 and human milk fat globulin 1, and the basal myoepithelial cells were positive for alpha-smooth muscle actin and S-100 protein. Estrogen and progesterone hormone receptors were focally and weakly positive for luminal epithelium. Although no mammary-like glands were present in the dermis around the tumor, this unusual apocrine tumor has been suggested to be derived from male anogenital mammary-like glands and mimic a mammary-like gland adenoma in the male perineum

Eyelid Apocrine Hidrocystomas in a Cat

Background: Eyelid apocrine hidrocystoma (AH) is a benign cystic lesion originating from the glands of Moll. These eyelid lesions are rare in cats and there are few cases reported in the literature. The aetiopathogenesis of AH is unknown and the lesion has been interpreted either as proliferative adenomatous tumour or as retention cyst. Defnitive diagnosisrequires biopsy with microscopic examination. Treatment options for eyelid AH include surgical excision, drainage through aspiration, cryosurgery with liquid nitrogen and chemical ablation. The aim is to report a case of bilateral multiple AH of the eyelids in a cat that was successfully treated with surgical excision.Case: A 5-year-old male Himalayan cat was referred to the Ophthalmology Section in the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil with a history of pigmented masses in both eyes that had been progressively enlarging over a 1-year period. Ophthalmic examination revealed two cysts on themedial canthus at the eyelid margin in both eyes. In the left eye was observed mild blepharospasm and lacrimation. Cysts were soft, smooth, round and flled with a dark brownish pigment. The remainder of the ophthalmic examination was unremarkable. Surgical excision of the cysts was indicated with a safety margin. The surgical procedure was performedunder inhalation anaesthesia using an operating microscope. A V-shaped, full-thickness excision of the eyelid containing the cyst was performed. The eyelids were closed with two layers of sutures. No complications were noted during surgery. Microscopic examination revealed cystic dilatation of the sweat glands with a large amount of eosinophilic secretion. EyelidAH was diagnosed based on the results to confrm the diagnosis. The cat recovered and was discharged the following day. The postoperative treatment involved the administration of tramadol (2 mg/kg, PO, q 12 h) daily for 3 days. After surgery, the cat had no signs of ocular discomfort. After three years, no recurrence has been observed.Discussion: AH is a benign tumour derived from Moll’s glands. The exact aetiology of AH is unknown. A breed-specifc predisposition among Persian cats has been suggested. In the present case, the ophthalmic examination revealed periocular masses brownish to black, round, soft, and fluid-flled. Multiple pigmented nodules involving the skin of the lower eyelids were observed. In the current case, the cat was of the Himalayan breed and was 5 years old with multiple AH in both eyelids. In terms of clinical features, this case was similar to previous ones reporting eyelid AH in cats. Normally, a defnitive diagnosis is confrmed through histopathology after excisional biopsy. In the current case, diagnose was made on the basis of the clinical fndings, history, and results of histological examination. Treatment options for eyelid AH include surgical excision, aspiration, cryosurgery and chemical ablation with trichloroacetic acid. Surgical removal of the cysts was performed in the current case. Histopathologic examination revealed cystic dilatation of the sweat gland with large amount of eosinophilic secretion. The sutures were removed one week after surgery. Periodic evaluations were conducted and there were no signs of recurrence after three years. In the present case, surgical excision was effective in the treatment of eyelid AH in a cat.Keywords: lid, cystic adenomas, feline