Automatic Autism Spectrum Disorder Detection Using Artificial Intelligence Methods with MRI Neuroimaging: A Review

Autism spectrum disorder (ASD) is a brain condition characterized by diverse signs and symptoms that appear in early childhood. ASD is also associated with communication deficits and repetitive behavior in affected individuals. Various ASD detection methods have been developed, including neuroimaging modalities and psychological tests. Among these methods, magnetic resonance imaging (MRI) imaging modalities are of paramount importance to physicians. Clinicians rely on MRI modalities to diagnose ASD accurately. The MRI modalities are non-invasive methods that include functional (fMRI) and structural (sMRI) neuroimaging methods. However, the process of diagnosing ASD with fMRI and sMRI for specialists is often laborious and time-consuming; therefore, several computer-aided design systems (CADS) based on artificial intelligence (AI) have been developed to assist the specialist physicians. Conventional machine learning (ML) and deep learning (DL) are the most popular schemes of AI used for diagnosing ASD. This study aims to review the automated detection of ASD using AI. We review several CADS that have been developed using ML techniques for the automated diagnosis of ASD using MRI modalities. There has been very limited work on the use of DL techniques to develop automated diagnostic models for ASD. A summary of the studies developed using DL is provided in the appendix. Then, the challenges encountered during the automated diagnosis of ASD using MRI and AI techniques are described in detail. Additionally, a graphical comparison of studies using ML and DL to diagnose ASD automatically is discussed. We conclude by suggesting future approaches to detecting ASDs using AI techniques and MRI neuroimaging

Automatic Diagnosis of Schizophrenia and Attention Deficit Hyperactivity Disorder in rs-fMRI Modality using Convolutional Autoencoder Model and Interval Type-2 Fuzzy Regression

Nowadays, many people worldwide suffer from brain disorders, and their health is in danger. So far, numerous methods have been proposed for the diagnosis of Schizophrenia (SZ) and attention deficit hyperactivity disorder (ADHD), among which functional magnetic resonance imaging (fMRI) modalities are known as a popular method among physicians. This paper presents an SZ and ADHD intelligent detection method of resting-state fMRI (rs-fMRI) modality using a new deep learning method. The University of California Los Angeles dataset, which contains the rs-fMRI modalities of SZ and ADHD patients, has been used for experiments. The FMRIB software library toolbox first performed preprocessing on rs-fMRI data. Then, a convolutional Autoencoder model with the proposed number of layers is used to extract features from rs-fMRI data. In the classification step, a new fuzzy method called interval type-2 fuzzy regression (IT2FR) is introduced and then optimized by genetic algorithm, particle swarm optimization, and gray wolf optimization (GWO) techniques. Also, the results of IT2FR methods are compared with multilayer perceptron, k-nearest neighbors, support vector machine, random forest, and decision tree, and adaptive neuro-fuzzy inference system methods. The experiment results show that the IT2FR method with the GWO optimization algorithm has achieved satisfactory results compared to other classifier methods. Finally, the proposed classification technique was able to provide 72.71% accuracy

Computer-Aided Diagnosis in Neuroimaging

This chapter is intended to provide an overview to the most used methods for computer-aided diagnosis in neuroimaging and its application to neurodegenerative diseases. The fundamental preprocessing steps, and how they are applied to different image modalities, will be thoroughly presented. We introduce a number of widely used neuroimaging analysis algorithms, together with a wide overview on the recent advances in brain imaging processing. Finally, we provide a general conclusion on the state of the art in brain imaging processing and possible future developments

Automated detection of depression from brain structural magnetic resonance imaging (sMRI) scans

 Automated sMRI-based depression detection system is developed whose components include acquisition and preprocessing, feature extraction, feature selection, and classification. The core focus of the research is on the establishment of a new feature selection algorithm that quantifies the most relevant brain volumetric feature for depression detection at an individual level

Construction of embedded fMRI resting-state functional connectivity networks using manifold learning

We construct embedded functional connectivity networks (FCN) from benchmark resting-state functional magnetic resonance imaging (rsfMRI) data acquired from patients with schizophrenia and healthy controls based on linear and nonlinear manifold learning algorithms, namely, Multidimensional Scaling, Isometric Feature Mapping, Diffusion Maps, Locally Linear Embedding and kernel PCA. Furthermore, based on key global graph-theoretic properties of the embedded FCN, we compare their classification potential using machine learning. We also assess the performance of two metrics that are widely used for the construction of FCN from fMRI, namely the Euclidean distance and the cross correlation metric. We show that diffusion maps with the cross correlation metric outperform the other combinations

Contributions to the Modelling of Auditory Hallucinations, Social robotics, and Multiagent Systems

165 p.The Thesis covers three diverse lines of work that have been tackled with the central endeavor of modeling and understanding the phenomena under consideration. Firstly, the Thesis works on the problem of finding brain connectivity biomarkers of auditory hallucinations, a rather frequent phenomena that can be related some pathologies, but which is also present in healthy population. We apply machine learning techniques to assess the significance of effective brain connections extracted by either dynamical causal modeling or Granger causality. Secondly, the Thesis deals with the usefulness of social robotics strorytelling as a therapeutic tools for children at risk of exclussion. The Thesis reports on the observations gathered in several therapeutic sessions carried out in Spain and Bulgaria, under the supervision of tutors and caregivers. Thirdly, the Thesis deals with the spatio-temporal dynamic modeling of social agents trying to explain the phenomena of opinion survival of the social minorities. The Thesis proposes a eco-social model endowed with spatial mobility of the agents. Such mobility and the spatial perception of the agents are found to be strong mechanisms explaining opinion propagation and survival