New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.This work has been supported by the Spanish Ministry of Education and Science (SAF 2003-07207-C02 and CT2004-5358), Comunidad de Madrid (GR/SAL/0850/ 2004), and UTE project FIMA. S.A.A.D.D. holds a predoctoral fellowship from the Ministry of Education for Associated Units to CSIC. D.C. thanks CSIC for a I3P Grant.Peer reviewe