3 research outputs found
From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing
The biomedical properties of a porous bio-collagenic polymer extracted from
leather industrial waste residues have been investigated in wound healing and tissue
regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to
induced wounds in rats dramatically improved its healing after 7 days in terms of collagen
production and wound filling as well as in the migration and differentiation of
keratinocytes. The formulation tested was found to be three times more effective than the
commercial reference product Catrix® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52,
p < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 vs. 2.17 ± 0.75, p < 0.001; Regeneration
of Epidermis (RE): 13.33 ± 5.11 vs. 5 ± 5.48, p < 0.05)
From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing
The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52, p vs. 2.17 ± 0.75, p vs. 5 ± 5.48, p < 0.05).Rafael Luque gratefully acknowledges support from the Spanish MICINN via the concession of a
Ramon y Cajal contract (ref. RYC-2009-04199) and funding under project P10-FQM-6711 (Consejeria
de Ciencia e Innovacion, Junta de Andalucia).We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)