Accuracy of available methods for quantifying the heat power generation of nanoparticles for magnetic hyperthermia

In magnetic hyperthermia, characterising the specific functionality of magnetic nanoparticle arrangements is essential to plan the therapies by simulating maximum achievable temperatures. This functionality, i.e. the heat power released upon application of an alternating magnetic field, is quantified by means of the specific absorption rate (SAR), also referred to as specific loss power (SLP). Many research groups are currently involved in the SAR/SLP determination of newly synthesised materials by several methods, either magnetic or calorimetric, some of which are affected by important and unquantifiable uncertainties that may turn measurements into rough estimates. This paper reviews all these methods, discussing in particular sources of uncertainties, as well as their possible minimisation. In general, magnetic methods, although accurate, do not operate in the conditions of magnetic hyperthermia. Calorimetric methods do, but the easiest to implement, the initial-slope method in isoperibol conditions, derives inaccuracies coming from the lack of matching between thermal models, experimental set-ups and measuring conditions, while the most accurate, the pulse-heating method in adiabatic conditions, requires more complex set-ups.Peer Reviewe