Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists

This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantiose-lective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as >true> enantioselective methods. Some examples are discussed in detail for each particular heading.Peer Reviewe