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    Long-term prognostic significance of response in multiple myeloma after stem cell transplantation

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    GEM (Grupo Español de MM) and PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatía Maligna) Cooperative Study Groups.-- et al.For establishing the true effect of different response categories in patients with multiple myeloma (MM) treated with autologous stem cell transplantation, we evaluated, after a median follow-up of 153 months, 344 patients with MM who received a transplant between 1989 and 1998. Overall survival (OS) at 12 years was 35% in complete response (CR) patients, 22% in near complete response (nCR), 16% in very good partial response (VGPR), and 16% in partial response (PR) groups. Significant differences in OS and progression-free survival were found between CR and nCR groups (P = .01 and P = .002, respectively), between CR and VGPR groups (P = .0001 and P = .003), or between CR and PR groups (P = .003 and P = 11 years of follow-up, possibly signifying a cure for patients in CR.This work was supported by the Fondo de Investigacio´n Sanitaria (FIS), the Instituto Carlos III, Ministerio de Sanidad (grant PI0089-01/2); the Cooperative Research Thematic Network (G03/ 136 and RD06/0020/0006); and the CRIS foundation.Peer Reviewe
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