2 research outputs found
EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewal
During early stages of neural development, neuroepithelial cells translocate their nuclei along the
apicobasal axis in a harmonized manner with the cell cycle. How cell cycle progression and
neuroepithelium polarity are coordinated remains unclear. It has been proposed that developmental
cues, epigenetic mechanisms and cell cycle regulators must be linked in order to orchestrate these
processes. We have recently discovered that a master epigenetic factor, EZH2 is essential to coordinate
these events. EZH2 directly represses the cell cycle regulator p21WAF1/CIP in the chicken spinal cord. By
doing so, EZH2 controls neural progenitor cell renewal and fine-tunes Rho signaling pathway, which is
essential to maintain neuroepithelial structure. Our findings point to a new role of EZH2 during
development that could have potential implication in other areas as cancer.Our study was supported by grants BFU-2012-34261 to
MAMB from the Spanish Ministry of Education and Science,
090210 from Fundacio La Marato de TV3 and Fondation
Jer^ome Lejeune to MAMB.Peer Reviewe