2 research outputs found

    DMSO affects Aβ<inf>1-40</inf>'s conformation and interactions with aggregation inhibitors as revealed by NMR

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    © The Royal Society of Chemistry 2015. We show via 3D-heteronuclear NMR spectroscopy that Aβ1-40 adopts a disordered conformational ensemble with fluctuating turns in DMSOd6. Using NMR, we map the binding sites of three water-insoluble aggregation inhibitors to Aβ1-40 in DMSOd6 and discover remarkable differences in Aβ1-40 recognition by a fourth inhibitor in H2O versus DMSOd6.Peer Reviewe
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