Carijodienone from the octocoral Carijoa multiflora. A spiropregnane-based steroid

Two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the Pacific octocoral Carijoa multiflora. Compound 1 possesses a novel spiropregnane-based steroidal skeleton. The photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at C-10 of 1. The antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.his work was supported by the Ministerio de Ciencia e Innovación (BIO2007-61745, SAF2009-08039, SAF2010-16858). A.R.D.-M. acknowledges financial support from Programa JAE-Doc (CSIC)