Asymmetric organocatalytic synthesis of γ-nitrocarbonyl compounds through Michael and Domino reactions

Recent advances in the organocatalytic enantioselective synthesis of γ-nitrocarbonyl compounds through Michael additions of either nitroalkanes to α,β-unsaturated carbonyl derivatives or enolizable carbonyl compounds to nitroalkenes are surveyed. Domino processes leading to structurally more complex products bearing the γ-nitrocarbonyl functionality are also reviewed. © 2010 Elsevier Ltd. All rights reserved.We thank for their support of our programs: the Spanish Ministry of Science and Innovation (MICINN. Madrid, Spain. Project CTQ2007-67532-C02-01, CTQ2009-09028 and CTQ2010-19606), FEDER Program, and the Government of Aragon (Zaragoza, Spain. Project PI064/09).Peer Reviewe