1 research outputs found
New acyclic receptors containing pyridazine units. The influence of pi-stacking on the selective transport of lipophilic phenethylamines
Abstract—The synthesis of four new series of acyclic heteroaromatic receptors is described. They are built by two flexible polyether chains
functionalised at their end with pyridazinone or methylpyridazine rings and connected by pyridine or benzene units. Their ability as carriers
of lipophilic and hydrophilic phenethylamines and metallic cations has been evaluated. Transport rates show that, in general, these compounds are much more efficient carriers of lipophilic amines than of dopamine and NaC,KC and Ca2C ions. Their transport selectivities
towards phenethylamine and homoveratrylamine are discussed on the basis of their structural features. Molecular modelling studies suggest
that interaction of the aromatic moiety of the guest with the pyridazinone rings via double p-stacking, or with the pyridine ring by single
p-stacking, should be responsible of their enhanced efficacy and selectivity in the transport of lipophilic phenethylamines.The authors thank the Spanish Comision Interministerial de
Ciencia y Tecnologı´ a for financial support given to this
research work (SAF99-0063). We are also grateful to the
contributions of the Centro de Resonancia Magne´tica
Nuclear for determining the 1D NMR spectra and the
Centro de Microana´lisis of the Univ. Complutense de
Madrid for elemental analyses.Peer reviewe