1 research outputs found
Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus
11 páginas, 7 figuras, 2 tablasThe alternative pathway is considered to be the most ancient route for activation of the complement
system. Herein, we report the characterization of C3 and factor B-like proteins in the clam Ruditapes
decussatus, termed Rd-C3 and Rd-Bf-like. The Rd-C3 is a three-chain protein, similar to other protoC3
proteins, and the Rd-Bf-like is composed of two complement control protein modules (CCP domains)
that differ from other described Bf proteins. The inoculation of clams with live bacteria did not result in
induction of these functions, but inhibited the expression of Rd-C3 and Rd-Bf-like.This research has been supported by Ministerio de Educacio´n y
Ciencia (AGL2003-02454 and AGL2008-05111/ACU) and Xunta de
Galicia (PGIDIT06PXI402124PM).Peer reviewe