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    Studies on aromatic compounds Inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids

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    With the objective to understand structural features responsible for the biological activity, novel nonelectrophilic biphenyl derivatives and peptide-biphenyl hybrids have been synthesized and evaluated as calpain I inhibitors. The preliminary results indicate that the presence of additional aromatic rings (besides the biphenyl system) makes these compounds potent calpain inhibitors with IC50 values in the nanomolar range. 漏 2004 Elsevier Ltd. All rights reserved
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