Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain

The extraction of remote sensing signatures from a particular geographical region allows the generation of electronic signature maps, which are the basis to create a high-resolution collection atlas processed in continuous discrete time. This can be achieved using a new multispectral image classification approach based on pixel statistics for the class description. This is referred to as the Weighted Pixel Statistics Method. This paper explores the effectiveness of this novel approach developed for supervised segmentation and classification of remote sensing signatures, with a comparison with the traditional Weighted Order Statistics Method. The extraction of remote sensing signatures from real-world high-resolution environmental remote sensing imagery is reported to probe the efficiency of the developed technique. " 2008 IEEE.",,,,,,"10.1109/ICEEE.2008.4723424",,,"http://hdl.handle.net/20.500.12104/45721","http://www.scopus.com/inward/record.url?eid=2-s2.0-61549086787&partnerID=40&md5=a0238c026eeda282c3d7c2b85d8e6974",,,,,,,,"2008 5th International Conference on Electrical Engineering, Computing Science and Automatic Control, CCE 2008",,"53

Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain

Regular physical exercise mediates health and longevity promotion involving Sirtuin 1 (SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by means of fine-tuning the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway by preventing the transition of an originally pro-survival program into a pro-aging mechanism. Additionally, SIRT1 promotes mitochondrial function and reduces the production of reactive oxygen species (ROS) through regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), the master controller of mitochondrial biogenesis. Here, by using senescence-accelerated mice prone 8 (SAMP8) as a model for aging, we determined the effect of wheel-running as a paradigm for long-term voluntary exercise on SIRT1-AMPK pathway and mitochondrial functionality measured by oxidative phosphorylation (OXPHOS) complex content in the hippocampus and cortex. We found differential activation of SIRT1 in both tissues and hippocampal-specific activation of AMPK. These findings correlated well with significant changes in OXPHOS in the hippocampal, but not in the cerebral cortex, area. Collectively, the results revealed greater benefits of the exercise in the wheel-running intervention in a murine model of senescence, which was directly related with mitochondrial function and which was mediated through the modulation of SIRT1 and AMPK pathways. © 2014 Springer Science+Business Media New York

Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain

© 2014, Springer Science+Business Media New York. Regular physical exercise mediates health and longevity promotion involving Sirtuin 1 (SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by means of fine-tuning the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway by preventing the transition of an originally pro-survival program into a pro-aging mechanism. Additionally, SIRT1 promotes mitochondrial function and reduces the production of reactive oxygen species (ROS) through regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), the master controller of mitochondrial biogenesis. Here, by using senescence-accelerated mice prone 8 (SAMP8) as a model for aging, we determined the effect of wheel-running as a paradigm for long-term voluntary exercise on SIRT1-AMPK pathway and mitochondrial functionality measured by oxidative phosphorylation (OXPHOS) complex content in the hippocampus and cortex. We found differential activation of SIRT1 in both tissues and hippocampal-specific activation of AMPK. These findings correlated well with significant changes in OXPHOS in the hippocampal, but not in the cerebral cortex, area. Collectively, the results revealed greater benefits of the exercise in the wheel-running intervention in a murine model of senescence, which was directly related with mitochondrial function and which was mediated through the modulation of SIRT1 and AMPK pathways.This study was supported by grants SAF2010-15050 (PK), PSI2008-06417-C03-03 (RME), and SAF-2012-39852 (MP) from the “Ministerio de Educación y Ciencia” and 2009/SGR00893 from the “Generalitat de Catalunya.” S.B. was supported by a predoctoral fellowship (APIF) from the University of Barcelona. J.F.L. was supported by a predoctoral fellowship from the Generalitat de Catalunya (FI-DGR 2011)Peer Reviewe