A Simple and Ecofriendly One-Pot Synthesis of Highly Substituted 3-Cyanopyridine-Quinoline Hybrids via a Triphenyphosphine-Catalyzed Multicomponent Reaction Under Mild Conditions

A simple and convenient one-pot method has been used for the synthesis of new polycyclic compounds articulated around 3-cyanopyridine derivatives from 2-chloroquinolin-3-carbaldehydes, acetophenone derivatives, active methylene compounds, and ammonium acetate as a source of ammonia in the presence of catalytic amounts of PPh at room temperature. The salient features of the protocol used are mild reaction conditions, good yields, short reaction time, safety, and high atom economy. No column chromatographic was needed, and pure products were obtained by simple filtration and washing with EtO.WethankMinistère de l’Enseignement Supérieur et de la Recherche Scientifique (MESRS) Algeria, for financial support. Authors thank Pr. J. L. Marco-Contelles Instituto de Quimica Organica General (IQOG, CSIC, Madrid) Spain, for spectroscopic analysis.Peer Reviewe

A Simple and Ecofriendly One-Pot Synthesis of Highly Substituted 3-Cyanopyridine-Quinoline Hybrids via

A simple and convenient one-pot method has been used for the synthesis of new polycyclic compounds articulated around 3-cyanopyridine derivatives from 2-chloroquinolin-3-carbaldehydes, acetophenone derivatives, active methylene compounds, and ammonium acetate as a source of ammonia in the presence of catalytic amounts of PPh at room temperature. The salient features of the protocol used are mild reaction conditions, good yields, short reaction time, safety, and high atom economy. No column chromatographic was needed, and pure products were obtained by simple filtration and washing with EtO.WethankMinistère de l’Enseignement Supérieur et de la Recherche Scientifique (MESRS) Algeria, for financial support. Authors thank Pr. J. L. Marco-Contelles Instituto de Quimica Organica General (IQOG, CSIC, Madrid) Spain, for spectroscopic analysis.Peer Reviewe