A Dynamic Chemical Network for Cystinuria Diagnosis

The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non-covalent interactions, the design of stimulus-responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. The binding and sensing units are encoded in the components that dynamically assemble and disassemble responding to external stimuli as a successful tool to detect both cysteine and cystine in aqueous media. Moreover, the dynamic sensing system works in human urine, as a prospective application for cystinuria diagnosis. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimFinancial Support from MINECO/FEDER (CTQ2015-70117-R and BES-2013-063128), AGAUR (2014 SGR 231) and European Union (COST CM1304) are gratefully acknowledgedPeer reviewe