Successful pregnancy and delivery after a vitrified-warmed embryo transfer in a woman with Kallmann syndrome: A case report and literature review

Kallmann syndrome, a congenital disorder of idiopathic hypogonadotropic hypogonadism associated with anosmia, results in infertility because of anovulation. Assisted reproductive technology (ART) is considered when optimal ovulation induction therapy is difficult or when several cycles of ovulation induction therapy do not result in pregnancy. However, evidence is lacking regarding the optimal ART treatment for Kallmann syndrome. We report the case of a 33-year-old woman who successfully achieved pregnancy and delivery after ART treatment. At 29 years old, she was diagnosed with Kallmann syndrome due to hypothalamic amenorrhea and anosmia. At 33 years old, she revisited the hospital, desiring a child after one year of infertility. Due to anovulation, she was treated with gonadotropin therapy, but controlling follicular development was difficult, and thus ART treatment was initiated. The controlled ovarian stimulation (COS) protocol for ART treatment employed gonadotropins, recombinant follicular stimulating hormone/human menopausal gonadotropin plus human chorionic gonadotropin, to promote follicular growth. Four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. After vitrified-warmed embryo transfer of a morula stage embryo in a hormone replacement cycle, pregnancy was achieved but resulted in a miscarriage. A second oocyte retrieval was performed under the same COS; four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. Further, a pregnancy was achieved through the vitrified warmed embryo transfer. At 40 weeks and 6 days of gestation, a baby boy weighing 3,344 g with an Apgar score of 7/8 was delivered vaginally. The mother's postpartum course and neonate were free from adverse events. For women with Kallmann syndrome, ART treatment and selective embryo cryopreservation may be a reasonable and safe option

CLINICO-STATISTICAL OBSERVATION ON THE OUT-PATIENTS AT DEPARTMENT OF ORAL AND MAXILLOFACIAL SURGERY, NARA MEDICAL UNIVERSITY HOSPITAL DURING THE FIRST FIVE YEARS

The authors performed clinico-statistical observation on 10,013 out-patients who presented during the five years following the inception of Department of Oral and Maxillofacial Surgery, Nara Medical University Hospital, on 19th October 1976. The results are as follows : 1. The yearly average number of out-patients was 2,003, which was the largest of any Departmant of Dentistry and/or Oral and Maxillofacial Surgery Medical University Hospital. 2. 7,448 patients (74.4%) had diseases associated with oral and maxillofacial surgery, who were divided into the following 14 groups : inflammations (21.8%), traumas (19.4%), diseases of temporomandibular joint (12.1%), diseases of oral mucosa (8.7%), impacted teeth (7.1%), cysts (6.9%), tumors and tumor-like diseases (5.6%), anomalies (3.7%), diseases of salivary gland (2.3%), iatrogenic diseases (1.9%), diseases of nervous system (1.3%), blood diseases (0.5%), jaw deformities (0.2%), and others (7.8%). 3. 7,273 patients (72.6%) were referred by dentists (30.7%), medical doctors (35.9%) and others (6.0%). Patients with diseases of TMJ were referred by orthopedists (25.1%) more than dentists (22.1%), which suggests that this disease has not been generally recognized yet. 4. In 1,812 patients with general dental diseases, 832 patients (45.9%) had systemic diseases

第三回韓国言語文化研修で得たもの

pp152-156は非公開Article信大日本語教育研究 3: 131-159 (2003)departmental bulletin pape

ヤマガタ ダイガク ダイイチゲカ ２０ネン ノ シュジュツ チリョウ セイセキ

1998年から2018年までの20年間に山形大学第一外科で手術治療を行った食道癌197例、胃癌1079例、大腸癌1146例、肝細胞癌102例、肝内胆管癌32例、胆管癌118例、胆嚢癌65例、通常型膵癌151例、膵管内乳頭状粘液性腫瘍152例、膵・十二指腸神経内分泌腫瘍33例、乳癌272例の手術症例の臨床的特徴と予後をまとめたので報告する。全体としては20年間の長期において、それぞれの時代における最先端の治療を考慮しながら診療（診断、手術治療）を行ってきた。術前化学療法を施行するか否か、その時の抗がん剤の種類は何かなど、年代で変化しており、それぞれに対応してきた面がある。手術におけるリンパ節郭清・神経叢郭清の程度や臓器温存の程度も、20年前と現在では大きく変化している。したがってある疾患の、ある年代の特定の治療を行った術後生存曲線の報告と今回の検討を細かく比較していくのには無理が生じる可能性がある。これは20年の術後成績をまとめたものであることが孕んでいるLIMITATIONでもある。逆にこのような長期の成績を一定の見方でまとめたことに意味があるとも言える。それぞれの年代におけるそれぞれの臓器の手術後の生存曲線については、全国のレベルに比較しまったく遜色ないものである

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The outpatient clinic of Higashi-Nippon-Gakuen University School of Dentistry was opened in December, 1978 and the inpatient division was established in June, 1980. The total number of inpatients was 290 and that of outpatients was 3117 up till May, 1985. Clinical and statistical observations of inpatients over the past 5 years was analysed. The number of inpatients shouted a yearly increase up till 1983. The distribution of diseases of the inpatients is as follows : Cyst disorders (60cases ; 20.7%), tumors (58 cases ; 20.1%), facial malformations and jaw deformities (46 cases ; 15.9%), inflammatory cases (19 cases ; 6%), atroqhic alveolar ridges (14 cases ; 4.8%), traumata (25 cases ; 8.6%), and others (56 cases ; 17.9%). It is concluded that number of cystic and tumor diseases accounted for a large percentage of the total number of inpatients

The Development of the Transmission Vibration Test System Based on Labview

文章介绍了一个基于虚拟仪器技术开发的变速箱振动测试与分析系统。该系统实现了汽车变速箱振动信号的检测、分析、处理和显示存储,满足对测试过程高精度、自动化、智能化等各项测试要求

A Genetic Algorithm for Job-shop Scheduling Problem with Alternative Machine

描述了可变机器约束的Job shop调度问题模型 ,并提出了一种基于遗传算法的调度算法进行求解 .采用了一种新的基于操作的染色体编码方式 ,用二维矩阵的形式在机器的表达形式上扩展了传统基于操作的编码方式 .在进化过程中设计了一种改变算子附加信息方法的操作 ,用于扩展种群的变化方式和算法的搜索范围 .最后 ,分别以满足交货期和总加工时间最小为调度目标进行了数值计算 ,表明了该方法的有效性

Self-Organizing Neural Network Based On LabVIEW and Its Application

文章介绍了自组织神经网络在故障诊断方面的应用原理,针对自组织神经网络实现问题提出了一种通过在LabVIEW调用MATLAB应用程序实现自组织神经网络的方法。并通过轴承故障诊断的实例,证明了这种方法的有效性